Evaluating the in vivo glial response to miniaturized parylene cortical probes coated with an ultra-fast degrading polymer to aid insertion

Journal of Neural Engineering
Meng-Chen LoJeffrey D Zahn

Abstract

Despite the feasibility of short-term neural recordings using implantable microelectrodes, attaining reliable, chronic recordings remains a challenge. Most neural recording devices suffer from a long-term tissue response, including gliosis, at the device-tissue interface. It was hypothesized that smaller, more flexible intracortical probes would limit gliosis by providing a better mechanical match with surrounding tissue. This paper describes the in vivo evaluation of flexible parylene microprobes designed to improve the interface with the adjacent neural tissue to limit gliosis and thereby allow for improved recording longevity. The probes were coated with an ultrafast degrading tyrosine-derived polycarbonate (E5005(2K)) polymer that provides temporary mechanical support for device implantation, yet degrades within 2 h post-implantation. A parametric study of probes of varying dimensions and polymer coating thicknesses were implanted in rat brains. The glial tissue response and neuronal loss were assessed from 72 h to 24 weeks post-implantation via immunohistochemistry. Experimental results suggest that both probe and polymer coating sizes affect the extent of gliosis. When an appropriate sized coating dimension (100 µm  ×  10...Continue Reading

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Citations

Jun 2, 2018·Journal of Neural Engineering·Luis J GomezAngel V Peterchev
Jun 23, 2018·Journal of Neural Engineering·J Evan Smith, Angel V Peterchev
Aug 23, 2018·Journal of Neural Engineering·Jolien PasGeorge G Malliaras
Aug 22, 2018·Journal of Neural Engineering·Aman S AberraWarren M Grill
Apr 30, 2021·Frontiers in Cellular Neuroscience·Ouzéna Bouadi, Tuan Leng Tay

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