Evaluating the methods used for measuring cerebral blood flow at rest and during exercise in humans.

European Journal of Applied Physiology
Michael M TymkoKurt J Smith

Abstract

The first accounts of measuring cerebral blood flow (CBF) in humans were made by Angelo Mosso in ~1880, who recorded brain pulsations in patients with skull defects. In 1890, Charles Roy and Charles Sherrington determined in animals that brain pulsations-assessed via a similar method used by Mosso-were altered during a variety of stimuli including sensory nerve stimulation, asphyxia, and pharmacological interventions. Between 1880 and 1944, measurements for CBF were typically relied on skull abnormalities in humans. Thereafter, Kety and Schmidt introduced a new methodological approach in 1945 that involved nitrous oxide dilution combined with serial arterial and jugular venous blood sampling. Less than a decade later (1950's), several research groups employed the Kety-Schmidt technique to assess the effects of exercise on global CBF and metabolism; these studies demonstrated an uncoupling of CBF and metabolism during exercise, which was contrary to early hypotheses. However, there were several limitations to this technique related to low temporal resolution and the inability to measure regional CBF. These limitations were overcome in the 1960's when transcranial Doppler ultrasound (TCD) was developed as a method to measure beat...Continue Reading

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Citations

Jan 17, 2019·High Altitude Medicine & Biology·Mathew G RiegerAli M McManus
Oct 1, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hannah V FurbyRichard G Wise
Oct 15, 2019·Medicine and Science in Sports and Exercise·Takaaki KomiyamaSoichi Ando
Apr 30, 2020·The Journal of Physiology·Thomas A CalverleyDamian M Bailey
May 14, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catherine L JarrettRussell S Richardson
Sep 17, 2020·Future Cardiology·Mark DayerStuart D Rosen
Sep 29, 2019·European Journal of Applied Physiology·Hailey C LafaveTrevor A Day
May 7, 2021·Journal of the International Neuropsychological Society : JINS·Jill N BarnesKathleen B Miller
May 29, 2021·Sports Medicine - Open·Blake G Perry, Samuel J E Lucas

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Methods Mentioned

BETA
PCA
imaging techniques

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