Evaluating the next generation of RSV intervention strategies: a mathematical modelling study and cost-effectiveness analysis.

BMC Medicine
David HodgsonKatherine E Atkins

Abstract

With a suite of promising new RSV prophylactics on the horizon, including long-acting monoclonal antibodies and new vaccines, it is likely that one or more of these will replace the current monoclonal Palivizumab programme. However, choosing the optimal intervention programme will require balancing the costs of the programmes with the health benefits accrued. To compare the next generation of RSV prophylactics, we integrated a novel transmission model with an economic analysis. We estimated key epidemiological parameters by calibrating the model to 7 years of historical epidemiological data using a Bayesian approach. We determined the cost-effective and affordable maximum purchase price for a comprehensive suite of intervention programmes. Our transmission model suggests that maternal protection of infants is seasonal, with 38-62% of infants born with protection against RSV. Our economic analysis found that to cost-effectively and affordably replace the current monoclonal antibody Palivizumab programme with long-acting monoclonal antibodies, the purchase price per dose would have to be less than around £4350 but dropping to £200 for vaccinated heightened risk infants or £90 for all infants. A seasonal maternal vaccine would hav...Continue Reading

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Citations

Dec 30, 2020·Microorganisms·Sonia BianchiniSusanna Esposito
Jul 25, 2021·International Journal of Environmental Research and Public Health·Mónica López-LacortFrancisco J Santonja Gómez

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Software Mentioned

Mathematica
POLYMOD

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