Evaluating the novel application of cyclosporine 0.1% in ocular surface disease

Expert Opinion on Pharmacotherapy
Konstadinos G Boboridis, Anastasios G P Konstas

Abstract

Ocular surface disease (OSD) is a highly prevalent symptomatic condition caused by dry eye disease (DED), intrinsic, environmental, or iatrogenic causes. It affects patient's visual function and quality of life. Its pathophysiology is centered on tear hyperosmolarity, inflammation, and epithelial damage. Current management is suboptimal and includes artificial tear supplementation and short-term use of topical steroids in severe cases. The recent approval of cyclosporine 0.1% has transformed management strategies of severe DED and moderate-to-severe OSD. Areas covered: This review summarizes existing information on the efficacy, safety, and tolerability of the new cyclosporine 0.1% formulation. Expert opinion: Topical cyclosporine A 0.1% represents a promising, novel medication for the management of DED, Meibomian gland dysfunction, and inflammatory OSD. It is primarily beneficial for those patients requiring topical immunomodulatory therapy. This topical formulation also has the potential to meaningfully improve the management of moderate-to-severe glaucoma therapy-related OSD. Currently there is limited published clinical data concerning the efficacy of topical cyclosporine. There are, however, theoretical advantages when com...Continue Reading

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Citations

Feb 27, 2019·Ocular Immunology and Inflammation·Kostas G BoboridisAnastasios Gp Konstas
May 30, 2020·Ocular Immunology and Inflammation·Louis TongChristophe Baudouin
Oct 23, 2020·Ophthalmology and Therapy·Mohamud A VerjeeChristopher E Starr
Jan 23, 2021·Expert Opinion on Drug Safety·Anastasios G KonstasChristophe Baudouin
Aug 28, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jonghwa KimKyung Chul Yoon
Jan 29, 2022·Acta Ophthalmologica·Luca AgnifiliLeonardo Mastropasqua

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