Evaluating the pharmacoeconomic effect of adding tiotropium bromide to the management of chronic obstructive pulmonary disease patients in Singapore

Respiratory Medicine
Kang-Hoe LeeTow-Keang Lim

Abstract

To perform a pharmacoeconomic analysis on the treatment of chronic obstructive pulmonary disease (COPD) with the addition of tiotropium bromide. Pharmacoeconomic modeling was performed utilizing the efficacy of tiotropium bromide from the literature on different settings and severity of COPD. Reductions in exacerbations, hospitalizations, and number of exacerbation days per year were derived from these studies. Cost of drug treatment, exacerbations, hospitalization, and loss of income were derived from local data in Singapore and reported in Singapore dollars (US$1=S$1.71). A model was constructed to calculate the impact of one-year treatment with tiotropium bromide, and the results were reported for the total incremental cost per year, cost per year needed to reduce one hospitalization in one year, and cost-savings from hospitalizations in one year. Sensitivity analysis were performed for different number of patients treated per year, differing cost of hospitalization, different cost for tiotropium bromide, different impact of tiotropium bromide on clinical outcomes, and the different amount of substitution drug utilized in the comparator group. Using the different clinical effects and looking at the impact on treating 1000, 2...Continue Reading

Citations

Jan 1, 2010·ClinicoEconomics and Outcomes Research : CEOR·Shalini NaikThomas J Mattei
Apr 18, 2013·Journal of Evaluation in Clinical Practice·Steven Simoens
Nov 5, 2015·Journal of Medical Economics·Thomas R EinarsonMichiel E H Hemels
Jun 28, 2014·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Richard J MilneHarry Rea
Aug 31, 2010·PharmacoEconomics·Douglas W MapelJeno P Marton
Nov 19, 2010·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·O ZanioloM Miravitlles

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