Evaluating the promise of inclusion of African ancestry populations in genomics.

NPJ Genomic Medicine
Amy R BentleyCharles N Rotimi

Abstract

The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are becoming increasingly appreciated. The paucity of data on individuals with African ancestry is especially noteworthy as Africa is the birthplace of modern humans and harbors the greatest genetic diversity. It is expected that greater representation of those with African ancestry in genomic research will bring novel insights into human biology, and lead to improvements in clinical care and improved understanding of health disparities. Now that major efforts have been undertaken to address this failing, is there evidence of these anticipated advances? Here, we evaluate the promise of including diverse individuals in genomic research in the context of recent literature on individuals of African ancestry. In addition, we discuss progress and achievements on related technological challenges and diversity among scientists conducting genomic research.

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Citations

Jun 5, 2020·Circulation Research·Lindsay Fernández-RhodesKari E North
Oct 3, 2020·Frontiers in Genetics·Jessica N Cooke BaileyDana C Crawford
Sep 6, 2020·International Journal of Molecular Sciences·James F Read, Anthony Bosco
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Jan 14, 2021·Scientific Reports·Brigitte GlanzmannCraig Kinnear
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Dec 30, 2020·Current Opinion in Genetics & Development·Nchangwi S MunungPontsho Moela
Jan 13, 2021·Nature Reviews. Genetics·Luisa PereiraMichèle Ramsay
Oct 24, 2020·Nature Medicine·George Adigbli

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Methods Mentioned

BETA
genotyping

Software Mentioned

TopMED
NeuroGAP

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