Evaluating the role of autologous mesenchymal stem cell seeded on decellularized pericardium in the treatment of myocardial infarction: an animal study

Cell and Tissue Banking
Abdol-Mohammad KajbafzadehZeynab Kashani

Abstract

Inappropriate left ventricular remodeling following myocardial infarction (MI) can result in subsequent severe dysfunction. In this study, we tested the hypothesis that decellularized pericardium (DP) or seeded pericardial patch with autologous adipose-derived mesenchymal stem cells (ADMSCs) could be safely used in a MI scar and could improve heart function. Twelve rabbits were randomly divided into three equal groups. Four weeks after MI induction by ligation of the left anterior descending artery in 12 rabbits, animals of G1 (n = 4) received DP patch with labeled ADMSCs. DP patch was implanted in animals of G2 (n = 4). Rabbits of G3 (n = 4) remained without any intervention after MI induction (control group). Serial examinations including echocardiography, electrocardiography (ECG), scanning electron microscopy, histology and immunohistochemistry (IHC) were performed to evaluate the efficacy of the implanted scaffolds on recovery of the infracted myocardium. The results demonstrated that left ventricular contractile function and myocardial pathological changes were significantly improved in rabbits implanted with either DP or ADMSC-seeded pericardium. However, the seeded pericardium was more effective in scar repairing 2 mont...Continue Reading

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Citations

Nov 6, 2018·Current Stem Cell Research & Therapy·Nasim KiaieArmita M Gorabi
Feb 12, 2019·Regenerative Medicine·Reza KhorramirouzAbdol-Mohammad Kajbafzadeh
Apr 7, 2020·Journal of Biomaterials Science. Polymer Edition·Ilyas InciHuseyin Avci

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

Image Pro
Photoshop
SPSS
Statistical Package of Social Science

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