Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients.

JAMA Oncology
Tobias FehlmannAndreas Keller

Abstract

The overall low survival rate of patients with lung cancer calls for improved detection tools to enable better treatment options and improved patient outcomes. Multivariable molecular signatures, such as blood-borne microRNA (miRNA) signatures, may have high rates of sensitivity and specificity but require additional studies with large cohorts and standardized measurements to confirm the generalizability of miRNA signatures. To investigate the use of blood-borne miRNAs as potential circulating markers for detecting lung cancer in an extended cohort of symptomatic patients and control participants. This multicenter, cohort study included patients from case-control and cohort studies (TREND and COSYCONET) with 3102 patients being enrolled by convenience sampling between March 3, 2009, and March 19, 2018. For the cohort study TREND, population sampling was performed. Clinical diagnoses were obtained for 3046 patients (606 patients with non-small cell and small cell lung cancer, 593 patients with nontumor lung diseases, 883 patients with diseases not affecting the lung, and 964 unaffected control participants). No samples were removed because of experimental issues. The collected data were analyzed between April 2018 and November 2...Continue Reading

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Citations

Sep 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lisha YingDan Su
Sep 14, 2020·Journal of Clinical Laboratory Analysis·XiaoTing ZhouLingYun Dong
Nov 26, 2020·Nature Communications·Tobias FehlmannAndreas Keller
Dec 3, 2020·Journal of Clinical Medicine·J Luis Espinoza, Le Thanh Dong
Dec 4, 2020·Journal of Hematology & Oncology·Tianming ZhaoHui Zeng
Dec 12, 2020·Nucleic Acids Research·Fabian KernEckart Meese
Nov 26, 2020·International Journal of Molecular Sciences·Young-Ho Ahn, Yoon Ho Ko
Mar 31, 2021·International Journal of Cancer. Journal International Du Cancer·Kevin Ten HaafMartin C Tammemägi
Jul 3, 2021·Cancers·Cora Palanca-BallesterAlfonso Calvo
Aug 8, 2021·Cancers·Elisa DamaFabrizio Bianchi

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