Evaluating the utility of N1,N12-diacetylspermine and N1,N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yoshifumi UmemoriNaoki Watanabe

Abstract

Among natural polyamines, the concentrations of the diacetylated form of spermine and spermidine increase in the urine of patients with cancer. We evaluated the utility of urinary N(1),N(12)-diacetylspermine (DiAcSpm) and N(1),N(8)-diacetylspermidine (DiAcSpd) as tumor markers for breast and colorectal cancers. Urinary DiAcSpm and DiAcSpd concentrations were measured by an enzyme-linked immunosorbent assay. Urine and serum samples were collected from 33 and 28 patients with colorectal and breast cancers, respectively. The sensitivity of urine samples to DiAcSpm and DiAcSpd concentrations was compared with serum concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen CA 15-3 in breast cancer patients and with serum concentrations of CEA and CA 19-9 in colorectal cancer patients, respectively. In breast cancer patients, the sensitivity of DiAcSpm and DiAcSpd was 46.4% and 14.2%, respectively, which was higher than that of CEA and CA 15-3. In patients with colorectal cancer, the sensitivity of DiAcSpm and DiAcSpd was 69.6% and 36.3%, respectively. CEA was the second sensitive marker and CA 19-9 was the least sensitive marker in these patients. DiAcSpm is a highly sensitive tumor marker. DiAcSpm can serve as a pow...Continue Reading

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Citations

Mar 17, 2016·Nature Reviews. Molecular Cell Biology·Caroline H JohnsonGary Siuzdak
Nov 5, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Merja R HäkkinenJouko Vepsäläinen
Oct 28, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xidong ShaoYubo Li
Mar 10, 2018·International Journal of Molecular Sciences·Tetsushi NakajimaMasahiro Sugimoto
Jun 13, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Riikka Johanna NiemiJohanna U Mäenpää
Nov 12, 2019·Journal of Clinical Laboratory Analysis·Xiaoting LiuChengbin Wang
Aug 25, 2019·International Urology and Nephrology·Ismail SelviOzlem Kaymaz
Aug 24, 2018·Journal of the National Cancer Institute·Johannes F FahrmannSamir Hanash
Jul 30, 2019·Frontiers in Nutrition·Nelly C Muñoz-EsparzaM Carmen Vidal-Carou
Aug 29, 2021·Pediatric Surgery International·Kazuki YokotaMasao Kawakita

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