Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI

PloS One
Xiuhua DingAlzheimer’s Disease Neuroimaging Initiative

Abstract

Memory assessment is a key factor for the diagnosis of cognitive impairment. However, memory performance over time may be quite heterogeneous within diagnostic groups. To identify latent trajectories in memory performance and their associated risk factors, we analyzed data from Alzheimer's Disease Neuroimaging Initiative (ADNI) participants who were classified either as cognitively normal or as Mild Cognitive Impairment (MCI) at baseline and were administered the Rey Auditory Verbal Learning test (RAVLT) for up to 9 years. Group-based trajectory modeling on the 30-minute RAVLT delayed recall score was applied separately to the two baseline diagnostic groups. There were 219 normal subjects with mean age 75.9 (range from 59.9 to 89.6) and 52.5% male participants, and 372 MCI subjects with mean age 74.8 (range from 55.1 to 89.3) and 63.7% male participants included in the analysis. For normal subjects, six trajectories were identified. Trajectories were classified into three types, determined by the shape, each of which may comprise more than one trajectory: stable (~30% of subjects), curvilinear decline (~ 28%), and linear decline (~ 42%). Notably, none of the normal subjects assigned to the stable stratum progressed to dementia ...Continue Reading

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Citations

Mar 9, 2021·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Benjamin David WilliamsTarani Chandola
May 11, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Zimu WuUNKNOWN ASPREE Investigator Group
Jun 1, 2021·Journal of Alzheimer's Disease : JAD·Shama D KaranthErin L Abner
Oct 13, 2021·Journal of Clinical and Experimental Neuropsychology·Meta M BoennigerMonique M B Breteler
Dec 8, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yizhe GaoUNKNOWN CHAP, UKBB, ADNI, ROSMAP, LLFS, NIA-LOAD and ADGC consortia

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Software Mentioned

SAS
RAVLT
GBTM

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