PMID: 8580783Dec 1, 1995Paper

Evaluation and comparison of an immunochemical and a guaiac faecal occult blood screening test for colorectal neoplasia

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
P RozenN Papo

Abstract

Guaiac tests for faecal occult blood are used for colorectal neoplasia screening. Specificity may be improved by using an immunochemical test for human blood. We evaluated and compared, within an endoscopic study, an immunochemical test for human stool albumin, BM-Test Colon Albumin, with the guaiac test, Hemoccult SENSA. Both tests were given to 527 screenees who had had a low-peroxidase diet before and during the tests. All had a colonoscopic (59%) or flexible sigmoidoscopic (41%) examination. Both tests were easy to perform and develop. They were of similar sensitivity (35-30%) for adenomas > or = 1.0 cm in diameter or cancers, but Colon Albumin had a higher specificity (90%) than Hemoccult (85%; P < 0.05). The latter, however, had a higher sensitivity for neoplasia of all sizes (25% vs 20%; NS) but lower specificity (85% vs 90%; P < 0.05). Colon Albumin was positive in 11.2%, while Hemoccult SENSA was positive in 16.7% and appears very sensitive to dietary peroxidases. Positivity was reduced to 7% by changing the methodology protocol. Overall, the guaiac test is more sensitive but less specific than the immunochemical test for colorectal neoplasia. However, the technical and diagnostic limitations of these tests must be app...Continue Reading

Citations

Mar 7, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akheel A SyedBibi A Khatoon
Aug 6, 1998·Alimentary Pharmacology & Therapeutics·J E Allison
Apr 29, 2014·Clinical Biochemistry·Magdalen R R CarrollStephen P Halloran
Oct 21, 2009·Clinics in Laboratory Medicine·Kimberly W Sanford, Richard A McPherson
Dec 11, 2014·Digestive Diseases and Sciences·Graeme P YoungHelen E Seaman
Aug 18, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jean FaivreCatherine Lejeune
Sep 4, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·E M TweedleA J M Watson
Apr 15, 2008·Current Opinion in Gastroenterology·Banchob Sripa, Chawalit Pairojkul
Aug 3, 2007·BJU International·Dler Besarani, David Cranston
Jul 1, 2004·The British Journal of Surgery·T MakJ Hill

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