Abstract
As coprocessed excipients (CPE) gain a lot of focus recently, this article compares three commercially available CPE of Avicel brand, namely, CE 15, DG, and HFE 102. Comparison is based on measured physical properties of coprocessed mixtures, respectively, flow properties, pycnometric density, mean particle size, specific surface area, moisture content, hygroscopicity, solubility, pH leaching, electrostatic charge, SEM images, and DSC. Tablets were made employing three pressure sets. Viscoelastic properties and ejection force were assessed during compression, as well as pycnometric density, mass uniformity, height, tensile strength, friability, disintegration, and wetting times. Avicel CE 15 is of mid-range flow properties, contains mid-size and nonspherical particles, and has high hygroscopicity, growing negative charge, best lubricity, lowest tensile strength, and mid-long disintegration times. Avicel DG possesses the worst flow properties, small asymmetrical particles, lowest hygroscopicity, stable charge, intermediate lubricity, and tensile strength and exhibits fast disintegration of tablets. Finally, Avicel HFE 102 has the best flow properties, large symmetrical particles, and middle hygroscopicity and its charge fluctuat...Continue Reading
References
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·R C Rowe
May 1, 1970·Journal of Pharmaceutical Sciences·J T Fell, J M Newton
Apr 17, 1999·International Journal of Pharmaceutics·M G Vachon, D Chulia
Dec 28, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S WestermarckJ Yliruusi
Feb 9, 2000·Pharmaceutical Science & Technology Today·I JivrajC M Thomson
Mar 8, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M Kuentz, H Leuenberger
Mar 29, 2000·Journal of Pharmaceutical Sciences·A BurgerH Stöttner
Mar 7, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J S WuM T Sheu
Sep 2, 2005·Journal of Pharmaceutical Sciences·Changquan Calvin Sun
Dec 7, 2006·International Journal of Pharmaceutics·M George, T E Abraham
Feb 24, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Y GonnissenC Vervaet
Feb 28, 2007·International Journal of Pharmaceutics·Michael G Herting, Peter Kleinebudde
May 1, 2008·AAPS PharmSciTech·Rakhi B ShahMansoor A Khan
Sep 10, 2008·International Journal of Pharmaceutics·Sameer G LateAjay K Banga
Oct 16, 2008·Journal of Pharmaceutical Sciences·Yu PuCharles Cooney
Feb 26, 2009·Expert Opinion on Drug Delivery·Sumit Saha, Aliasgar F Shahiwala
Apr 24, 2009·AAPS PharmSciTech·Abhay GuptaMansoor A Khan
Jan 22, 2010·Pharmaceutical Development and Technology·Sherif I F BadawyMunir Hussain
Apr 22, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ingvild KlevanGöran Alderborn
Nov 6, 2010·AAPS PharmSciTech·Nidal DaraghmehAdnan Badwan
Nov 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Joachim BrouwersEvelijn Zeijdner
Mar 31, 2011·Drug Development and Industrial Pharmacy·Sameh Abdel-Hamid, Gabriele Betz
May 14, 2011·Pharmaceutical Development and Technology·Sameh Abdel-Hamid, Gabriele Betz
Sep 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alvaro GoyanesRamón Martínez-Pacheco
Jun 19, 2012·Indian Journal of Pharmaceutical Sciences·Rajashree MasareddyV Shah
Sep 4, 2012·AAPS PharmSciTech·Anna KrupaKrystyna Wodnicka
Feb 8, 2013·Expert Opinion on Drug Delivery·Ali Al-khattawi, Afzal R Mohammed
Aug 15, 2013·Pharmaceutical Development and Technology·Raman Mahadevan IyerWaseem Malick
Oct 5, 2013·Pharmaceutical Development and Technology·Oluwatomide Adeoye, Gbenga Alebiowu
Oct 31, 2013·Drugs in R&D·David HobbsJoel Raskin
Jan 24, 2014·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Barbora Vraníková, Jan Gajdziok
Mar 4, 2014·Journal of Food Science and Technology·Deepak MudgilBhupendar Singh Khatkar
Jun 20, 2012·Carbohydrate Polymers·María D TorresMaría J Vázquez
Jul 6, 2014·International Journal of Pharmaceutics·Gregory ThoorensBrigitte Evrard
Oct 10, 2014·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Jan MuselíkIvana Lukášová
Mar 18, 2015·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Jitka MužíkováVáclav Lochař
Apr 7, 2015·International Journal of Pharmaceutics·SongTao WangRiccardo Panicucci
Jun 16, 2015·Journal of Pharmaceutical Sciences·Samy YassinJ Axel Zeitler
Jun 16, 2015·BioMed Research International·Barbora VraníkováDavid Vetchý
Apr 3, 2016·AAPS PharmSciTech·Saadya A TayelMohamed H H AbouGhaly
Aug 3, 2016·AAPS PharmSciTech·Sohil I ChauhanJayant R Chavda
Jun 6, 2017·Drug Development and Industrial Pharmacy·Ian SoulairolTahmer Sharkawi
Jun 8, 2017·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Aleš FrancJan Muselík
Oct 1, 2015·Journal of Pharmaceutical Sciences·Samy YassinJ Axel Zeitler