Evaluation and Detection of Dysplasia in IBD: the Role of Chromoendoscopy and Enhanced Imaging Techniques

Current Treatment Options in Gastroenterology
Anna M Buchner, Gary R Lichtenstein

Abstract

Patients with ulcerative colitis (UC) and Crohn's disease (CD) colitis are at significantly higher risk for the development of colitis-associated colorectal cancer (CAC), a risk associated with increased duration and extent of disease [1]. CAC in patients with ulcerative colitis and Crohn's colitis arises from dysplastic tissue in the background of mucosal inflammatory changes. Regular surveillance by colonoscopy is a recommended cancer prevention strategy endorsed by the US and European GI societies [2-4]. Until recently, random sampling of the mucosa throughout the colon has been the mainstay of this conventional surveillance. This requires multiple biopsies to be taken and processed, a practice which is time consuming, expensive, and has a low diagnostic yield. The growth pattern of dysplastic tissue is often multifocal and diffuse, and thus, its detection may not be optimal with the use of traditional white light colonoscopy. According to recent studies, most dysplastic lesions appear to be visible to careful endoscopic inspection [5-7]. Thus, the approach focusing on targeted biopsies of any mucosal abnormalities instead of only random biopsies has been advocated [8]. In addition, the detection and further delineation of a...Continue Reading

References

Aug 28, 2004·Gastrointestinal Endoscopy·Matthew D RutterAlastair Forbes
Mar 1, 2005·Inflammatory Bowel Diseases·Steven H ItzkowitzUNKNOWN Crohn's and Colitis Foundation of America Colon Cancer in IBD Study Group
Apr 25, 2007·Gastrointestinal Endoscopy·David T RubinStephen B Hanauer
Mar 6, 2008·JAMA : the Journal of the American Medical Association·Roy M SoetiknoShai Friedland
Jun 24, 2008·Scandinavian Journal of Gastroenterology·Wojciech BlonskiGary R Lichtenstein
Jan 14, 2010·The American Journal of Gastroenterology·Asher KornbluthUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Apr 30, 2010·Gut·Stuart R CairnsUNKNOWN Association of Coloproctology for Great Britain and Ireland
May 23, 2012·The American Journal of Gastroenterology·Ana IgnjatovicBrian P Saunders
Sep 26, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P SuY Bai
Feb 24, 2015·Gastroenterology·Loren LaineUNKNOWN SCENIC Guideline Development Panel
Feb 25, 2015·Gastrointestinal Endoscopy·Loren LaineUNKNOWN SCENIC Guideline Development Panel
Mar 25, 2015·Gastrointestinal Endoscopy·UNKNOWN ASGE Standards of Practice CommitteeJohn M DeWitt
May 9, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ludger LeifeldUNKNOWN Detect Dysplasia Study Group
Jul 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Erik Mooiweer, Bas Oldenburg

❮ Previous
Next ❯

Citations

Sep 17, 2019·Annual Review of Vision Science·Mario MatthaeiAlbert S Jun
Aug 29, 2019·Nature Reviews. Gastroenterology & Hepatology·NaNa Keum, Edward Giovannucci
Feb 6, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Massimo Claudio Fantini, Ilaria Guadagni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.