Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer

Drug Delivery and Translational Research
Heba F SalemKhaled R A Abdellatif

Abstract

Tamoxifen citrate (TXC) is commonly indicated to prevent cell multiplication and development of breast cancer. However, it is usually associated with limited activity and development of toxicity and resistance. This study aimed to describe an in situ pH-responsive niosomes as a carrier for localized and sustained delivery of TXC. The thin film hydration method was utilized to produce TXC niosomes using sorbitan monostearate and cholesterol of 1:1 Molar ratio. The produced formula displayed nano-spherical shape with entrapment efficiency (EE) of 88.90 ± 0.72% and drug release of 49.2 ± 1.51% within 8 h. This formula was incorporated into chitosan/glyceryl monooleate (CH/GMO) as a localized in situ pH-responsive hydrogel delivery system. Different formulae were produced by Design-Expert software based on user-defined response surface design utilizing different chitosan concentration (A) and GMO concentration (B) characterized for mean viscosity (R2) and in vitro release studies (R1). The results displayed that R1 was significantly antagonistic with both of A and B while R2 was significantly synergistic with both of them. The optimum formula was selected and capped with gold as an ideal candidate for computed tomography (CT) to ev...Continue Reading

References

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Aug 1, 2015·Drug Design, Development and Therapy·Heba F SalemMahmoud M Omar
Feb 3, 2016·Drug Design, Development and Therapy·Heba F SalemMahmoud M Omar

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Citations

Jul 30, 2019·Drug Development and Industrial Pharmacy·Heba F SalemDemiana M Naguib
Apr 24, 2019·Nanomaterials·Beatriz García-PinelJuan M López-Romero

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Methods Mentioned

BETA
Differential scanning calorimetry
dynamic light scattering
transmission electron microscopy
light microscopy
X-ray

Software Mentioned

Design
Expert
Expert®

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