Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline.

The Journal of Clinical Endocrinology and Metabolism
Mark E MolitchPatricia A Stephens

Abstract

The objective is to provide guidelines for the evaluation and treatment of adults with GH deficiency (GHD). The chair of the Task Force was selected by the Clinical Guidelines Subcommittee of The Endocrine Society (TES). The chair selected five other endocrinologists and a medical writer, who were approved by the Council. One closed meeting of the group was held. There was no corporate funding, and members of the group received no remuneration. Only fully published, peer-reviewed literature was reviewed. The Grades of Evidence used are outlined in the Appendix. Consensus was achieved through one group meeting and e-mailing of drafts that were written by the group with grammatical/style help from the medical writer. Drafts were reviewed successively by the Clinical Guidelines Subcommittee, the Clinical Affairs Committee, and TES Council, and a version was placed on the TES web site for comments. At each level, the writing group incorporated needed changes. GHD can persist from childhood or be newly acquired. Confirmation through stimulation testing is usually required unless there is a proven genetic/structural lesion persistent from childhood. GH therapy offers benefits in body composition, exercise capacity, skeletal integrity...Continue Reading

References

Dec 1, 1992·Archives of Disease in Childhood·S L HyerS S Nussey
Feb 1, 1991·Journal of Applied Physiology·R C CuneoP H Sönksen
Jun 3, 1989·Lancet·J O JørgensenJ S Christiansen
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·B M Arafah
Sep 1, 1986·The American Journal of Medicine·P J SnyderT A Gennarelli
Mar 1, 1987·Archives of Disease in Childhood·P E ClaytonS M Shalet
Jan 1, 1968·The Journal of Pediatrics·R L HintzJ F Sotos
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·K A ZuppingerO Oetliker
Apr 30, 1994·Lancet·D M HoffmanK K Ho
Aug 1, 1995·Clinical Endocrinology·S J Holmes, S M Shalet
Aug 1, 1995·Clinical Endocrinology·S J Holmes, S M Shalet
May 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D TeegardenC M Weaver
Dec 15, 1993·JAMA : the Journal of the American Medical Association·J E FradkinL L Robison
Sep 1, 1993·Acta Endocrinologica·T RosénB A Bengtsson
Aug 26, 1993·The New England Journal of Medicine·S MalozowskiG A Fleming
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M TauberP Rochiccioli
Jan 1, 1997·Clinical Endocrinology·B BülowE M Erfurth
Feb 1, 1997·European Journal of Endocrinology·V MarkussisD G Johnston
Oct 23, 1997·European Journal of Endocrinology·T RosénB A Bengtsson
Feb 21, 1998·Annals of Internal Medicine·H N HodisS P Azen
Sep 24, 1998·The Journal of Clinical Endocrinology and Metabolism·H B BaumA Klibanski
Nov 14, 1998·The Journal of Clinical Endocrinology and Metabolism·W M DrakeJ P Monson

❮ Previous
Next ❯

Citations

Nov 15, 2006·Applied Microbiology and Biotechnology·Jolanta SereikaiteVladas-Algirdas Bumelis
Nov 2, 2006·Pituitary·M DogaA Giustina
Feb 1, 2007·Pituitary·Christoph J Auernhammer, George Vlotides
Apr 6, 2007·Pituitary·Claire E HighamPeter J Trainer
Apr 13, 2007·Pituitary·Anita Y M Kwan, Mark L Hartman
Apr 13, 2007·Pituitary·Martin Bidlingmaier, Christian J Strasburger
Mar 14, 2008·Pituitary·Olivia Pereira, John S Bevan
Apr 12, 2008·Pituitary·V GascoE Ghigo
Aug 2, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Steven Chernausek
Jan 24, 2009·Nature Clinical Practice. Endocrinology & Metabolism·Ken H Darzy
Sep 22, 2009·The Analyst·Asta Kausaite-MinkstimieneArunas Ramanavicius
Nov 10, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fred SattlerStanley Azen
Feb 9, 2012·Cardiology in Review·Christopher R PalmeiroIrene A Weiss
Dec 23, 2011·The Journal of Head Trauma Rehabilitation·Jessica SchniedersHans de Boer
Feb 23, 2013·Molecular and Cellular Biology·Yugong HoNancy E Cooke
Feb 7, 2008·Hormone Research·Kirstine StochholmClaus Højbjerg Gravholt
Nov 6, 2013·BMC Endocrine Disorders·Steffen Kristian FleckChristin Spielhagen
Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Apr 16, 2011·Endocrine Reviews·Frederic CastinettiSally A Camper
Mar 19, 2009·The Journal of Clinical Endocrinology and Metabolism·Fred R SattlerStanley P Azen
Dec 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Manuel H Aguiar-OliveiraRoberto Salvatori
Mar 2, 2010·The Journal of Clinical Endocrinology and Metabolism·Alexander T Faje, Ariel L Barkan
Sep 20, 2006·Endocrine Journal·P Del MonteD Bernasconi
Aug 23, 2011·European Journal of Endocrinology·Ahmad HazemMohammad Hassan Murad
Aug 26, 2011·European Journal of Endocrinology·Ahmad HazemMohammad Hassan Murad
Nov 16, 2012·European Journal of Endocrinology·Valentina GascoGianluca Aimaretti
Jul 5, 2007·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Naomi Hizuka
Oct 27, 2011·Pharmacogenomics·Silke HartlebUNKNOWN German KIMS Pharmacogenetics Study Group
Sep 1, 2008·Journal of Clinical Research in Pediatric Endocrinology·Merih BerberoğluIlknur Arslanoğlu
Sep 8, 2011·Indian Journal of Endocrinology and Metabolism·K S BrarK M Suryanarayana
Sep 1, 2009·Journal of Clinical Research in Pediatric Endocrinology·Mitchell E Geffner
Jan 22, 2010·European Journal of Endocrinology·Charlotte HöybyeBeverly M K Biller
Sep 30, 2008·European Journal of Endocrinology·Martin Bidlingmaier
Sep 23, 2008·European Journal of Endocrinology·V GascoE Ghigo
Feb 11, 2010·European Journal of Endocrinology·Hiroyoshi AkutsuChristof Schöfl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.