Evaluation and validation of a Crohn's disease inflammatory activity index reflecting pattern of endoscopic severity

Scandinavian Journal of Gastroenterology
B SimonisR Gladisch

Abstract

This study was designed to investigate objective variables assessing the inflammatory activity of Crohn's disease accessible for routine management and their suitability to act as surrogate indicators for endoscopic alterations. Thirty-six patients were included in a prospective study and underwent endoscopic investigation, 18 with clinically exacerbated disease and 18 after acute-phase conservative therapy. The endoscopic findings were classified to define the dependent variable, yielding two categoric levels: acute active disease and remission. The extent of affected mucosal area was not taken into consideration. The serum variables alpha1-antitrypsin, acid alpha1-glycoprotein (AGP), C-reactive protein (CRP), sialic acids, prealbumin (PAB), and albumin were used as independent variables to predict the dependent variable. To compare the results with common indices, the Crohn's Disease Activity Index (CDAI) and van Hees Index were calculated. The following model was calculated by stepwise logistic regression analysis: if AGP (mg/dl) -4.2 x PAB (mg/dl) > or =0.8, then endoscopically active disease will be predicted with a sensitivity of 100% and a specificity of 95% (P < 0.001). The predictive values of the single variables, CDA...Continue Reading

References

Oct 1, 1992·Gastroenterologia Japonica·R BabaH Obata
Nov 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·M B TutenZ Leider
Apr 1, 1980·Gut·P A van HeesJ H van Tongeren
Sep 29, 1994·The New England Journal of Medicine·P RutgeertsH Lorenz-Meyer
Jan 1, 1993·Scandinavian Journal of Gastroenterology·J Kjeldsen, O B Schaffalitzky de Muckadell
Jun 13, 1996·The New England Journal of Medicine·A BelluzziM Miglioli
Jul 1, 1995·Inflammatory Bowel Diseases·H J Hodgson, M Bhatti

❮ Previous
Next ❯

Citations

Aug 1, 2007·Inflammatory Bowel Diseases·Itta M MinderhoudBas Oldenburg
Apr 9, 2016·Inflammatory Bowel Diseases·Sandra M QuezadaRaymond K Cross
Oct 17, 2009·Digestive Diseases and Sciences·Farid LjucaNada Pavlovic-Calic
Jan 6, 2006·Journal of Clinical Gastroenterology·Gil Weitzman, Charles Maltz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Canadian Journal of Public Health = Revue Canadienne De Santé Publique
L F KOYL
Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
P F D BowlesJ C Fleming
© 2022 Meta ULC. All rights reserved