Evaluation between the Usability and Physicochemical Property of Acyclovir Ointments

Journal of Pharmaceutics
Yutaka InoueIkuo Kanamoto

Abstract

A lot of prescription medicines have become switch over-the-counter (OTC) medicines. However, additives in brand-name drugs, generic drugs, and switch OTC drugs differ; therefore, the feelings associated with the use of these medicines vary for patients. The aim of this study was to compare the physicochemical properties and the feeling of use (assuming skin as an index of usability) of acyclovir (ACV) ointments. Five ACV ointments were used: ACV-A, a brand-name drug, ACV-B and ACV-C, generic drugs, and ACV-D and ACV-E, switch OTC drugs. The physicochemical properties were evaluated by determining the content uniformity, water content, flattening, viscosity and viscoelasticity, and near-infrared (NIR) absorption spectroscopy. Skin friction was measured to evaluate the feeling associated with use. Results of the content uniformity test indicated that the ACV content was uniform, and equivalence was observed. Measurement of moisture content indicated that this parameter differed in each ointment preparation. The yield value, which was calculated by measuring flattening, was 4416.7 dyne/cm2 for ACV-A, 1175.7 dyne/cm2 for ACV-B, 2114.9 dyne/cm2 for ACV-C, 4234.5 dyne/cm2 for ACV-D, and 3620.7 dyne/cm2 for ACV-E. Measurement of visc...Continue Reading

References

May 28, 2005·Archives of Pharmacal Research·Eun-Jung SuhHyo-Jin Kim
Nov 17, 2009·Advances in Colloid and Interface Science·Eveline FredrickKoen Dewettinck
Jan 15, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Renjini Joseph, K Girish Kumar
May 12, 2011·AAPS PharmSciTech·Morten Jonas MaltesenHolger Grohganz
Jul 4, 2012·International Journal of Pharmaceutics·Yutaka InoueIkuo Kanamoto
May 3, 2013·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Patrícia NetoPaulo Costa
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