Evaluation for sleep apnea in patients with Ehlers-Danlos syndrome and Marfan: a questionnaire study

Clinical Genetics
J VerbraeckenE F Wouters

Abstract

Sleep complaints are frequently reported by patients with Marfan and Ehlers-Danlos syndrome (EDS). We examined the exact nature of sleep complaints in these patients. A representative sample of Marfan and EDS patients responded to a general sleep questionnaire, including the Epworth Sleepiness Scale (ESS) and the Medical Outcomes Study Short-Form 36 (SF-36) health-related quality of life (QOL) questionnaire. Fifteen Marfan patients and 9 EDS patients were evaluated and compared to 24 healthy controls, matched for age, sex and body mass index. Maintaining sleep was frequently disturbed in Marfan (40%, p < 0.04) as well as in EDS patients (56%, p < 0.01). Sleep apnea was exclusively reported by Marfan patients (27%, p = 0.03). Periodic limb movements were much more reported in EDS (67%, p = 0.02) than in Marfan (27%, p = 0.25) compared to controls (8%). Pain and back complaints were highly presented in both groups, but most pronounced in EDS patients (47% in Marfan versus 77% in EDS). No differences for the scores in the ESS were found. For all SF-36 questionnaire items, scores were much lower in patient groups, except for emotional problems. We found that sleep complaints were not rare in Marfan and EDS patients and correlated w...Continue Reading

References

Jun 1, 1991·Lancet·P A Cistulli, C E Sullivan
Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·W A DeBackerP Van deHeyning
Mar 1, 1993·The American Review of Respiratory Disease·P A Cistulli, C E Sullivan
Jan 1, 1995·Respiration; International Review of Thoracic Diseases·J A VerbraeckenW De Backer
May 1, 1997·Spine·W R HobbsR E Pyeritz
Aug 1, 1997·Journal of Pain and Symptom Management·A SachetiP Tsipouras
Aug 8, 1998·Respiration Physiology·J VerbraeckenW De Backer
Feb 24, 2000·International Journal of Nursing Studies·B BerglundK Lützén
Mar 16, 2000·The Laryngoscope·J F Piccirillo
Aug 30, 2000·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·C StepnowskyS Ancoli-Israel

❮ Previous
Next ❯

Citations

Oct 11, 2012·PloS One·Dounya SchoormansAeilko H Zwinderman
Dec 18, 2008·Industrial Health·Joris C VersterBerend Olivier
Sep 14, 2004·Orthodontics & Craniofacial Research·Catharine HagbergJan Andersson-Norinder
Apr 21, 2016·Rheumatology·Inge De WandeleFransiska Malfait
Jun 10, 2017·Journal of the American College of Cardiology·Judith Z GoldfingerUNKNOWN GenTAC Registry Consortium
May 13, 2014·Clinical Genetics·G VelvinA Ø Geirdal
Dec 9, 2016·Research in Developmental Disabilities·Stijn De BaetsDominique van de Velde
Feb 2, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Brad TinkleHoward Levy
Feb 1, 2011·Cephalalgia : an International Journal of Headache·Elise M BendikVincent T Martin
Dec 25, 2004·European Heart Journal·Philip MoonsSabina De Geest
Nov 20, 2016·American Journal of Medical Genetics. Part a·Traci J SpeedClaudia M Campbell
Apr 20, 2014·Clinical Rheumatology·Ilknur AlbayrakGülten Karaca
Feb 7, 2015·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Marco CastoriPaola Grammatico
Mar 31, 2015·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Marco CastoriPaola Grammatico
Jul 9, 2010·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Svend Rand-HendriksenArnstein Finset
Nov 27, 2015·Clinical Genetics·G VelvinA Ø Geirdal
Jan 6, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Gry VelvinAmy Østertun Geirdal
Jun 20, 2018·Current Osteoporosis Reports·Vito Guarnieri, Marco Castori
Dec 2, 2020·Health and Quality of Life Outcomes·Thy Thy VanemCecilie Røe
Jan 5, 2021·Pediatric Cardiology·Erin Walker MacKintoshLuciana Young
Apr 8, 2021·American Journal of Medical Genetics. Part a·Kiana L MartinezChristina M Laukaitis
Nov 23, 2021·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Andrea Bulbena-CabréAntonio Bulbena

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cephalalgia : an International Journal of Headache
Elise M BendikVincent T Martin
International Journal of Nursing Studies
Britta BerglundK Lützén
Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Britta Berglund, G Nordström
The British Journal of Psychiatry : the Journal of Mental Science
Jessica A EcclesHugo D Critchley
Journal of Pain and Symptom Management
A SachetiP Tsipouras
© 2022 Meta ULC. All rights reserved