Evaluation of [(11)C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis

European Journal of Nuclear Medicine and Molecular Imaging
David Vállez GarciaJanine Doorduin

Abstract

Evaluation of translocator protein (TSPO) overexpression is considered an attractive research tool for monitoring neuroinflammation in several neurological and psychiatric disorders. [(11)C]PK11195 PET imaging has been widely used for this purpose. However, it has a low sensitivity and a poor signal-to-noise ratio. For these reasons, [(11)C]CB184 was evaluated as a potentially more sensitive PET tracer. A model of herpes simplex encephalitis (HSE) was induced in male Wistar rats. On day 6 or 7 after virus inoculation, [(11)C]CB184 PET scans were acquired followed by ex vivo evaluation of biodistribution. In addition, [(11)C]CB184 and [(11)C]PK11195 PET scans with arterial blood sampling were acquired to generate input for pharmacokinetic modelling. Differences between the saline-treated control group and the virus-treated HSE group were explored using volumes of interest and voxel-based analysis. The biodistribution study showed significantly higher [(11)C]CB184 uptake in the amygdala, olfactory bulb, medulla, pons and striatum (p < 0.05) in HSE rats than in control rats, and the voxel-based analysis showed higher bilateral uptake in the pons and medulla (p < 0.05, corrected at the cluster level). A high correlation was found b...Continue Reading

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Citations

Jul 13, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·E KurtysE F J de Vries
Dec 23, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paula Kopschina FeltesJanine Doorduin
Feb 24, 2017·EJNMMI Research·Isadora Lopes AlvesRonald Boellaard
Jan 13, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Erik NutmaBenjamin B Tournier
Mar 2, 2021·Acta Pharmaceutica Sinica. B·Lingling ZhangSteven H Liang
Jan 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andrea ParenteJanine Doorduin

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Software Mentioned

VINCI
SAMIT
OSEM
SPSS Statistics

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