PMID: 8998476Nov 1, 1995Paper

Evaluation of [123I] beta-CIT binding with SPECT in controls, early and late Parkinson's disease

Nuclear Medicine and Biology
R J VermeulenE A Van Royen

Abstract

The main neuropathological feature in Parkinson's disease (PD) is a severe degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of dopamine in the striatum. Recently, a new radioligand (beta-CIT) for single photon emission computed tomography (SPECT) became available for in vivo imaging of the dopamine transporter on nerve endings of dopaminergic neurons in the striatum. The present results demonstrate that [123I]-beta-CIT SPECT allows a discrimination between early and late PD patients. In our opinion, these preliminary data suggest that [123I]-beta-CIT SPECT should be used from now on in longitudinal studies (such as the DATATOP study) in which the effects of (putative) neuroprotective interventions in PD are monitored.

References

Jun 5, 1992·European Journal of Pharmacology·M GerlachM B Youdim
Jan 1, 1990·Acta Psychiatrica Scandinavica. Supplementum·L Farde, C von Bahr
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Jan 1, 1993·Journal of Neural Transmission. General Section·T BrückeI Podreka
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C D Ward
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B InnisS Wang
Sep 30, 1993·The New England Journal of Medicine·D B Calne
Jan 21, 1993·The New England Journal of Medicine·UNKNOWN Parkinson Study Group

❮ Previous
Next ❯

Citations

Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·J E AhlskogO L Burnett
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·A WinogrodzkaE C Wolters
Feb 20, 2004·Brain Research. Cognitive Brain Research·Shraga HochermanMiguel Schwartz
Jun 30, 2000·Nuclear Medicine Communications·W StaffenG Ladurner
Sep 6, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicolas NicastroPierre R Burkhard
Feb 24, 2015·Neurobiology of Aging·Valtteri KaasinenMarko Seppänen
Aug 18, 2018·The European Journal of Neuroscience·Emma L Lane
Nov 30, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Aline DelvaKoen Van Laere
Dec 23, 2021·Journal of Neurochemistry·Nicolas NicastroValentina Garibotto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.