PMID: 9179726May 1, 1997Paper

Evaluation of 13-week inhalation toxicity study on methyl t-butyl ether (MTBE) in Fischer 344 rats

Journal of Applied Toxicology : JAT
A W LingtonL S Andrews

Abstract

Methyl-t-butyl ether (MTBE) is widely used as an octane enhancing agent in gasoline. A 13-week inhalation study was conducted in Fischer 344 rats to provide information on potential target organs and toxicity of MTBE, and to ascertain a no-observed-adverse-effect level (NOAEL) for MTBE. Male and female Fischer 344 rats were exposed to target doses of MTBE vapor of 0, 800, 4000 and 8000 ppm for 6 h a day, 5 days per week for 13 weeks: MTBE produced no mortalities. At 8000 ppm, males and females showed a decrease in body weights compared to controls. The only notable effect on clinical observation was ataxia at 8000 ppm, which was apparent during the first 4 weeks of treatment. Mild hematological and clinical chemistry changes were observed in the 8000 ppm group. At 8000 ppm, animals showed increased serum levels of corticosteroids, which suggest some stress-like effect. At necropsy, there were no treatment-related gross lesions. Absolute and relative organ weights (liver, adrenals and kidneys) were increased in both sexes at 4000 and 8000 ppm, but there were no microscopic lesions in these tissues with the exception of the kidney. Microscopic examination of other tissues revealed no effects with the exception that at 8000 ppm, m...Continue Reading

Citations

Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Scott PhillipsAaron Brody
Nov 21, 2013·Drug and Chemical Toxicology·Katsumi MiyataKotaro Furukawa
Feb 17, 1998·Risk Analysis : an Official Publication of the Society for Risk Analysis·J J Clary
Dec 24, 1997·Risk Analysis : an Official Publication of the Society for Risk Analysis·H V Rao, G L Ginsberg
Nov 7, 2006·Regulatory Toxicology and Pharmacology : RTP·George CruzanMichael G Thomas
Dec 14, 2011·Journal of Applied Toxicology : JAT·Darol DoddEdilberto Bermudez
Jun 24, 2014·Regulatory Toxicology and Pharmacology : RTP·Derek SwickHerb Estreicher
Mar 26, 2009·Toxicology and Industrial Health·L Dong-meiH Xiao-dong
Jul 1, 2006·Critical Reviews in Toxicology·Douglas McGregor
Jul 25, 2014·International Journal of Occupational Medicine and Environmental Health·Marek Jakubowski, Sławomir Czerczak
May 26, 2001·Annual Review of Nutrition·R Mehrotra, J D Kopple
Aug 21, 2010·Critical Reviews in Toxicology·Douglas McGregor
Jan 18, 2017·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Christiane Vleminckx

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