Evaluation of 14-3-3 protein family levels and associated receptor expression of estrogen and progesterone in human uterine leiomyomas

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Liqun WangMing He

Abstract

Uterine leiomyomas represents a major public health problem. Despite their prevalence, the causation and pathogenesis of leiomyomas are poorly understood. A broad range of organisms and tissues contain 14-3-3 proteins which have been associated with the pathogenesis of many diseases through participating in signal transduction pathways. This study was designed to evaluate which 14-3-3 isoforms might be optimal targets in leiomyomas, and to further explore their relationship with estrogen and progesterone receptor (ER and PR). Paired samples of leiomyoma and adjacent myometrium were obtained from 80 subjects who had surgical excision of uterine leiomyomas. The expression of 14-3-3 isoforms was detected by Western bolt and RT-PCR, and their relationship with ER and PR was analysed by immunohistochemistry. The expressions of 14-3-3σ had decreased significantly in leiomyoma compared with that in normal myometrium and was negatively correlated with ER and PR by immunohistochemistry. The down-regulation of 14-3-3σ in leiomyoma suggests that 14-3-3σ may play a role in tumorigenesis, and that its mechanism may be involved in the up-regulation of ER and PR.

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Citations

Jun 20, 2020·BMC Complementary Medicine and Therapies·Yan LinDuan-Fang Liao
Nov 30, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Qi ShenXueqiong Zhu
Jul 3, 2021·The Journal of Obstetrics and Gynaecology Research·Bing-Jie WuFei Zhong
Nov 3, 2021·Virchows Archiv : an International Journal of Pathology·Bradley M TurnerFattaneh A Tavassoli

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