Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.

Carcinogenesis
Dezheng HuoOlufunmilayo Olopade

Abstract

Multiple breast cancer susceptibility loci have been identified in genome-wide association studies (GWAS) in populations of European and Asian ancestry using array chips optimized for populations of European ancestry. It is important to examine whether these loci are associated with breast cancer risk in women of African ancestry. We evaluated 25 single nucleotide polymorphisms (SNPs) at 19 loci in a pooled case-control study of breast cancer, which included 1509 cases and 1383 controls. Cases and controls were enrolled in Nigeria, Barbados and the USA; all women were of African ancestry. We found significant associations for three SNPs, which were in the same direction and of similar magnitude as those reported in previous fine-mapping studies in women of African ancestry. The allelic odds ratios were 1.24 [95% confidence interval (CI): 1.04-1.47; P = 0.018] for the rs2981578-G allele (10q26/FGFR2), 1.34 (95% CI: 1.10-1.63; P = 0.0035) for the rs9397435-G allele (6q25) and 1.12 (95% CI: 1.00-1.25; P = 0.04) for the rs3104793-C allele (16q12). Although a significant association was observed for an additional index SNP (rs3817198), it was in the opposite direction to prior GWAS studies. In conclusion, this study highlights the c...Continue Reading

References

Jun 3, 2000·Genetics·J K PritchardP Donnelly
Sep 11, 2002·Breast Cancer Research and Treatment·Kenneth C Chu, William F Anderson
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jul 5, 2006·Journal of the National Cancer Institute·Brenda J BoersmaStefan Ambs
Dec 23, 2006·American Journal of Human Genetics·Daniel J SchaidMichelle A T Hildebrandt
May 29, 2007·Nature·Douglas F EastonBruce A J Ponder
Oct 3, 2007·Breast Cancer Research and Treatment·Dezheng HuoOlufunmilayo I Olopade
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Feb 28, 2008·British Journal of Cancer·D HuoO I Olopade
Mar 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bert GoldKenneth Offit
Sep 25, 2008·International Journal of Cancer. Journal International Du Cancer·Barbara NemesureUNKNOWN Barbados National Cancer Study Group
Mar 31, 2009·Nature Genetics·Shahana AhmedDouglas F Easton
Aug 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dezheng HuoOlufunmilayo I Olopade
Oct 1, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wei ZhengWilliam J Blot
Dec 23, 2009·Genome Biology·Fouad ZakhariaHua Tang
Mar 25, 2010·Human Molecular Genetics·Miriam S UdlerAlison M Dunning
Apr 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Edward A Ruiz-NarváezJulie R Palmer
May 11, 2010·Nature Genetics·Clare TurnbullDouglas F Easton
Nov 9, 2010·Genetic Epidemiology·Yun LiGonçalo R Abecasis
Nov 13, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bao-Li ChangTimothy R Rebbeck
Jan 26, 2011·American Journal of Epidemiology·Edward A Ruiz-NarváezJulie R Palmer
Jan 26, 2011·Journal of the National Cancer Institute·Olivia FletcherJulian Peto
Sep 1, 2009·Molecular Ecology Resources·Melissa J HubiszJonathan K Pritchard
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Carolyn M HutterUlrike Peters
Aug 20, 2011·Human Molecular Genetics·Fang ChenChristopher A Haiman

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Citations

Apr 5, 2012·Journal of the National Cancer Institute·Jonine D Figueroa, Louise A Brinton
Nov 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie R PalmerLynn Rosenberg
Dec 24, 2013·Breast Cancer Research : BCR·Kara N Maxwell, Katherine L Nathanson
Nov 13, 2013·American Journal of Epidemiology·Katie M O'BrienRobert C Millikan
Dec 18, 2013·Cancer Causes & Control : CCC·Julie R PalmerAndrew F Olshan
Aug 28, 2012·Human Genetics·Fang ChenChristopher A Haiman
Jan 16, 2016·Hereditary Cancer in Clinical Practice·Gabriela C FernandesEdenir I Palmero
Jan 21, 2016·Journal of Medical Genetics·E L YoungS V Tavtigian
Nov 3, 2016·PloS One·Yoo-Jeong HanOlufunmilayo I Olopade
Jun 7, 2018·Molecular Carcinogenesis·Shengfeng WangYonglan Zheng
Jun 8, 2019·International Journal of Cancer. Journal International Du Cancer·Shengfeng WangOlufunmilayo I Olopade
Jun 27, 2017·NPJ Breast Cancer·Maureen E MurphyChristine B Ambrosone
Aug 23, 2020·International Journal of Molecular Sciences·Maria-Ancuta JurjIoana Berindan-Neagoe
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Iman AmraniLaila Abu Tahoun
May 17, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jiajun ShiWei Zheng
Feb 1, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jenna LilyquistFergus J Couch

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