Evaluation of 209 At as a theranostic isotope for 209 At-radiopharmaceutical development using high-energy SPECT

Physics in Medicine and Biology
Jason R CrawfordThomas J Ruth

Abstract

The development of alpha-emitting radiopharmaceuticals using 211At requires quantitative determination of the time-dependent nature of the 211At biodistribution. However, imaging-based methods for acquiring this information with 211At have not found wide-spread use because of its low abundance of decay emissions suitable for external detection. In this publication we demonstrate the theranostic abilities of the 211At/209At isotope pair and present the first-ever 209At SPECT images. The VECTor microSPECT/PET/CT scanner was used to image 209At with a collimator suitable for the 511 keV annihilation photons of PET isotopes. Data from distinct photopeaks of the 209At energy spectrum (195 keV (22.6%), 239 keV (12.4 %), 545 keV (91.0 %), a combined 782/790 keV peak (147 %), and 209Po x-rays (139.0 %)) were independently evaluated for use in image reconstructions using Monte Carlo (GATE) simulations and phantom studies. 209At-imaging in vivo was demonstrated in a healthy mouse injected with 10 MBq of free [209At]astatide. Image-based measurements of 209At uptake in organs of interest-acquired in 5 min intervals-were compared to ex vivo gamma counter measurements of the same organs. Simulated and measured data indicated that-due to the...Continue Reading

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Citations

Nov 25, 2020·Physics in Medicine and Biology·Minh Phuong NguyenFreek J Beekman
Feb 23, 2020·Cancer Biotherapy & Radiopharmaceuticals·Sture LindegrenEmma Aneheim
Jul 28, 2021·Biological Chemistry·Sabine SchulzeStefan Rammelt

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