Evaluation of 225Ac for vascular targeted radioimmunotherapy of lung tumors

Cancer Biotherapy & Radiopharmaceuticals
Stephen J KennelS Mirzadeh


Several alpha particle emitting radioisotopes have been studied for use in radioimmunotherapy. Ac-225 has the potential advantages of a relatively long half life of 10 days, and a yield of 4 alpha emissions in its decay chain with a total energy release of approximately 28 MeV. A new, 12 coordination site chelating ligand, HEHA, has been chemically modified for coupling to targeting proteins without loss of chelating ability. HEHA was coupled with MAb 201B which binds to thrombomodulin and accumulates efficiently in murine lung. Ac-225 was bound to the HEHA-MAb 201B conjugate and injected into BALB/c mice bearing lung tumor colonies of EMT-6 mammary carcinoma. Biodistribution data at 1 and 4 h postinjection indicated that, as expected, 225Ac was delivered to lung efficiently (> 300% ID/g). The 225Ac was slowly released from the lung with an initial t1/2 = 49 h, and the released 225Ac accumulated in the liver. Injection of free HEHA was only partially successful in scavenging free 225Ac. In addition to the slow release of 225Ac from the chelate, data indicated that decay daughters of 225Ac were also released from the lung. Immediately after organ harvest, the level of 213Bi, the third alpha-decay daughter, was found to be defici...Continue Reading


Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·Stephen J KennelG Kabalka
Feb 1, 1993·Nuclear Medicine Communications·M W GeerlingsR van der Hout
Feb 1, 1997·Hybridoma·T M BehrW S Becker
Jun 10, 1998·Nuclear Medicine and Biology·Stephen J Kennel, S Mirzadeh
Sep 2, 1998·European Journal of Nuclear Medicine·M R McDevittD A Scheinberg
Jul 2, 1999·British Journal of Cancer·Stephen J KennelS Mirzadeh
Jul 30, 1999·Journal of Medicinal Chemistry·K A DealM W Brechbiel
Sep 3, 1999·Nuclear Medicine and Biology·I A DavisStephen J Kennel
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·R E McLendonM R Zalutsky
Oct 1, 1982·Talanta·R Delgado, J J da Silva


Apr 21, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Olivier CouturierMichel Cherel
Jun 5, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Stephen J KennelS Mirzadeh
Sep 28, 2001·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·D MaD A Scheinberg
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·M W Brechbiel
Jun 2, 2001·Cancer Biotherapy & Radiopharmaceuticals·D E MilenicJeffrey Schlom
May 28, 2002·Cancer Biotherapy & Radiopharmaceuticals·Stephen J KennelS Mirzadeh
Oct 10, 2013·Cancer Biotherapy & Radiopharmaceuticals·Mark F McLaughlinStephen J Kennel
Nov 3, 2010·International Journal of Nanomedicine·Alessandro RuggieroM R McDevitt
Mar 15, 2011·Immunotherapy·Robert M Sharkey, David M Goldenberg
Sep 15, 2005·Clinical Medicine & Research·Arati V RaoDavid A Rizzieri
Mar 14, 2002·Expert Opinion on Biological Therapy·Michael L Salgaller
Apr 20, 2004·Nuclear Medicine and Biology·Gjermund HenriksenR H Larsen
Oct 23, 2004·Clinical Lymphoma·G L DeNardoS J DeNardo
Feb 10, 2018·Targeted Oncology·Mehran MakvandiJeffrey P Norenberg
Jun 12, 2018·Cancer Biotherapy & Radiopharmaceuticals·Nikki A Thiele, Justin J Wilson
Aug 15, 2000·Cancer Biotherapy & Radiopharmaceuticals·G Sgouros
Oct 1, 2017·Angewandte Chemie·Nikki A ThieleJustin J Wilson
May 15, 2002·Radiation Research·Stephen J KennelM W Brechbiel
Nov 1, 2013·Chemical Society Reviews·Eric W Price, Chris Orvig
Nov 7, 2019·Scientific Reports·Emma AneheimSture Lindegren
Aug 14, 2019·Scientific Reports·R M de KruijffA G Denkova
Apr 29, 2020·Pharmaceuticals·Mareike RoscherMartina Benešová
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhengsheng YaoJorge A Carrasquillo
Jul 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ase M BallangrudG Sgouros

Related Concepts

Alpha Radiation
Malignant Neoplasm of Lung
Mice, Inbred BALB C
Radiotherapy Dosage
Drug or Chemical Tissue Distribution

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Cancer Biotherapy & Radiopharmaceuticals
Stephen J KennelS Mirzadeh
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
M R McDevittD A Scheinberg
© 2021 Meta ULC. All rights reserved