Evaluation of 3D modality-independent elastography for breast imaging: a simulation study

Physics in Medicine and Biology
J J OuMichael I Miga

Abstract

This paper reports on the development and preliminary testing of a three-dimensional implementation of an inverse problem technique for extracting soft-tissue elasticity information via non-rigid model-based image registration. The modality-independent elastography (MIE) algorithm adjusts the elastic properties of a biomechanical model to achieve maximal similarity between images acquired under different states of static loading. A series of simulation experiments with clinical image sets of human breasts were performed to test the ability of the method to identify and characterize a radiographically occult stiff lesion. Because boundary conditions are a critical input to the algorithm, a comparison of three methods for semi-automated surface point correspondence was conducted in the context of systematic and randomized noise processes. The results illustrate that 3D MIE was able to successfully reconstruct elasticity images using data obtained from both magnetic resonance and x-ray computed tomography systems. The lesion was localized correctly in all cases and its relative elasticity found to be reasonably close to the true values (3.5% with the use of spatial priors and 11.6% without). In addition, the inaccuracies of surfac...Continue Reading

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Citations

Jan 10, 2012·Physics in Medicine and Biology·M M Doyley
Feb 13, 2010·Biomedical Engineering Online·Rowena E OngMichael I Miga
Aug 26, 2014·Radiology·Andrea S KlauserWerner R Jaschke
Sep 28, 2010·Progress in Biophysics and Molecular Biology·Prashanth DumpuriMichael I Miga
Jun 7, 2013·IEEE Transactions on Medical Imaging·Aristeidis SotirasNikos Paragios
Jun 22, 2011·IEEE Transactions on Bio-medical Engineering·Thomas S PheifferMichael I Miga

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