Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences

Annals of Surgical Oncology
F GrabellusG Taeger

Abstract

Isolated limb perfusion (TM-ILP) is an effective limb-sparing treatment for primarily nonresectable soft tissue sarcomas (STS). Surgical margins of STS after ILP were yet not systematically studied. In 47 patients with nonresectable STS, TM-ILP with subsequent tumor resection was performed. Surgical margins were systematically analyzed by light microscopy using the TNM and the Enneking classification. Furthermore, margins were analyzed for tumor regression in terms of improved resectability. Results were correlated with clinical and pathological parameters. Of 47 STS, 44 were classified as high-grade (93.6%) with a median tumor size of 10.0 cm. Primary limb-salvage rate was 85.1%. According to TNM resection margins were complete in 70.2% (R0) and incomplete in 29.8% (R1=21.3%, R2=8.5%). According to Enneking, 27.7% intralesional, 42.6% marginal, 21.3% wide, 2.1% radical, and 6.4% unclassifiable margins were found. Prior surgery and/or radiotherapy significantly decreased margin quality. Ten patients with incomplete resection (three intralesional, seven marginal) had no viable tumor at the plane of dissection, which was designated as "improved margins." Whereas those patients remained relapse free, five patients with viable tumo...Continue Reading

References

Dec 1, 1989·Acta Orthopaedica Scandinavica·A AlhoB Stener
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M CoindreG Contesso
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LewisM F Brennan
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C YangS A Rosenberg
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P H NijhuisH J Hoekstra
Apr 14, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C S TrovikA Wallöe
Nov 18, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F J LejeuneP F Leyvraz
Jan 5, 2002·The Journal of Bone and Joint Surgery. British Volume·C H GerrandA M Davis
Apr 16, 2002·Clinical Orthopaedics and Related Research·Walter W VirkusMark T Scarborough
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander StojadinovicMurray F Brennan
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyDavid C Harmon
Feb 3, 2004·Journal of Surgical Oncology·Mark D McKeeWilliam G Kraybill
Mar 17, 2004·Clinical Orthopaedics and Related Research·Noriyoshi KawaguchiYasushi Matsushita
Apr 6, 2004·CA: a Cancer Journal for Clinicians·Janice N Cormier, Raphael E Pollock
Jun 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S BonvalotA Le Cesne
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter W T Pisters
Apr 22, 2006·ANZ Journal of Surgery·Peter F M Choong
Apr 22, 2006·ANZ Journal of Surgery·Ian C DickinsonPeter Steadman
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Carl Jaffe
Aug 19, 2007·The British Journal of Surgery·M SampoC Blomqvist
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Yong Bae KimChang Ok Suh
Feb 26, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I NachmanyJ M Klausner
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·G TaegerS Ruchholtz

❮ Previous
Next ❯

Citations

May 4, 2013·Clinical Orthopaedics and Related Research·Patrick W O'DonnellDenis R Clohisy
Apr 26, 2014·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J JakobP Hohenberger
Apr 2, 2014·World Journal of Surgical Oncology·Lars Erik PodleskaGeorg Taeger
Oct 8, 2013·Hematology/oncology Clinics of North America·Joern Henze, Sebastian Bauer
Sep 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jan P DerooseCornelis Verhoef
Jan 28, 2017·International Journal of Surgery Case Reports·Javier López-GómezMario Cuellar-Hübbe
Dec 17, 2010·Annals of Surgical Oncology·Sylvie Bonvalot, Alessandro Gronchi
Jan 19, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·T AssiC Honoré

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.