PMID: 20625224Jul 14, 2010Paper

Evaluation of (99m)Tc-myocardial Perfusion SPECT Attenuation Correction by Hybrid SPECT/CT-Examination by Quantitative Analysis-

Nihon Hoshasen Gijutsu Gakkai zasshi
Yasuharu WakabayashiMasaki Shibasaki

Abstract

A non-uniform attenuation correction is necessary for the myocardial perfusion image (MPI) SPECT that is one of the images of the trunk. Simultaneous non-uniform attenuation correction during the process of SPECT reconstruction was enabled by developing hybrid SPECT/CT. Image acquisition of (99m)Tc MPI with hybrid SPECT/CT was performed in a phantom study and clinical cases. We evaluated the effect of non-uniform attenuation correction by Filtered Back Projection (FBP) or Ordered Subsets-Expectation Maximization (OS-EM) using visual analysis and quantitative analysis with a 17-segment model. The phantom study and the clinical cases differed somewhat as follows. In the phantom study, the count increased significantly with non-uniform attenuation correction in visual analysis and quantitative analysis. In the clinical cases, non-uniform attenuation correction increased the quantitative count in the basal and middle layer of the heart, and visual uniformity of the whole heart improved. However, the visual and quantitative count in the apex decreased with non-uniform attenuation correction. As a result, diagnostic performance for coronary heart disease is expected to be improved by this new technique using hybrid SPECT/CT.

References

Feb 15, 2002·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert C HendelTimothy M Bateman
Feb 22, 2005·Nuclear Medicine Communications·Christine M TongeMary C Prescott
Dec 14, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Yasmin MasoodFrans J Th Wackers
Jun 27, 2006·Nihon Hoshasen Gijutsu Gakkai zasshi·Harumi IguchiKazutaka Masuda
Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Tiziano SchepisPhilipp A Kaufmann
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Christopher L HansenUNKNOWN American Society of Nuclear Cardiology
Jan 15, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Rainer PreussWolfgang Burchert
Feb 22, 2008·Journal of Nuclear Medicine Technology·James A Patton, Timothy G Turkington

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