Evaluation of a 3-hour indium-111 leukocyte image as a surrogate for a technetium-99m nanocolloid marrow scan in the diagnosis of orthopedic infection

Clinical Nuclear Medicine
Jane A E DuttonA Michael Peters

Abstract

This is a retrospective study to evaluate a 3-hour In-111-labeled leukocyte image as a surrogate for a Tc-99m nanocolloid marrow scan in the investigation of suspected orthopedic infection using In-111 leukocyte scintigraphy. Images from 51 patients who had received contemporaneous In-111-labeled leukocyte scintigraphy and Tc-99m nanocolloid marrow scintigraphy were reviewed. Initially, the 3-hour and 22-hour In-111-labeled leukocyte images were compared. Sites of abnormal uptake on the 22-hour image were correlated with the 3-hour image and were graded according to the level of concordance or discordance. One week later, the Tc-99m nanocolloid images and 22-hour In-111-labeled leukocyte images of the same patients were compared and graded for concordance or discordance. When discrepancies in grading arose between the observers, a consensus opinion was achieved after additional review of the images a week later. On inspection of the 22-hour In-111 leukocyte images, 93 sites of focal, potentially abnormal leukocyte accumulation were identified. When the grading system was reduced to simply "concordant" or "discordant," there was good agreement between the observers in the majority of cases, with kappa statistics 0.77 for Tc-99m ...Continue Reading

References

Jan 1, 1990·European Journal of Nuclear Medicine·A D KingJ P Lavender
Jun 1, 1988·Nuclear Medicine Communications·A M PetersJ P Lavender
Nov 1, 1987·Nuclear Medicine Communications·M De SchrijverR Fridrich
Jul 1, 1986·AJR. American Journal of Roentgenology·D J PringJ P Lavender
Oct 1, 1983·Acta Orthopaedica Scandinavica·L MulambaA Vincent
Apr 1, 1995·European Journal of Nuclear Medicine·C AktolunA M Peters
Feb 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·W Y UssovA M Peters
May 16, 2000·Clinical Orthopaedics and Related Research·R E TellerD W Haas

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Citations

Jun 28, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P FernandezD Ducassou
Aug 19, 2005·Current Infectious Disease Reports·Santiago RestrepoHugo Cuellar
Jul 11, 2006·Nuclear Medicine Communications·Napoleone PrandiniAlberto Signore
May 23, 2006·Clinical Nuclear Medicine·Pierre AbouhamadThierry Vander Borght
Mar 4, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Manel RocaAlberto Signore
Mar 1, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Filip GemmelChristopher J Palestro
May 27, 2005·Journal of Biomedical Science·Gregory S MakowskiGale R Ramsby
Oct 12, 2013·Polish journal of radiology·Iwona Sudoł-Szopińska, Jarosław B Cwikła

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