Jan 1, 1992

Evaluation of a bilayer artificial skin capable of sustained release of an antibiotic

Biomaterials
K MatsudaY Ikada

Abstract

A bilayer artificial skin, composed of an upper silicone sheet and a lower collagen sponge, has been developed by modifying a technique proposed by Yannas and Burke. We have applied it clinically with success, but infection sometimes occurred in the area where the artificial skin was placed. To use it safely in an infected wound, we developed a new type of artificial skin capable of sustained release of antibiotic. Microspheres of poly-L-lactic acid containing an antibiotic, were installed in the upper silicone sheet. The usefulness of the new type of artificial skin was suggested by in vitro studies.

Mentioned in this Paper

Poly-l-lactic acid
Controlled-Release Preparations
Skin
Wound Healing
Silicones
Collagen Location
Tobracin
Depot Preparations
Hemocompatible Materials
Porcine Xenograft Dressings

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