Evaluation of a bladder tumor antigen test for the diagnosis of lower urinary tract malignancies in dogs

American Journal of Veterinary Research
Jean-Philippe H G BilletP E Holt

Abstract

To evaluate the use of a human bladder tumor antigen test for diagnosis of lower urinary tract malignancies in dogs. Urine samples from dogs without urinary tract abnormalities (n = 18) and from dogs with lower urinary tract neoplasia (20) or nonmalignant urinary tract disease (16). Test results were compared among groups and among 3 observers. The effects of urine pH and specific gravity, degree of hematuria, and storage temperature and time of urine samples on test results were also assessed. Test sensitivity and specificity were 90 and 94.4%, respectively, for differentiating dogs with lower urinary tract neoplasia from dogs without abnormalities. However, specificity decreased to 35% for differentiating dogs with neoplasia from dogs with nonmalignant urinary tract disease. In dogs with neoplasia, results were significantly affected by degree of hematuria. However, addition of blood to urine from dogs without hematuria had no significant effect on test results. Although intraobserver variation was significant, urine pH, specific gravity, or storage time or temperature had no significant effect on results. Although this bladder tumor antigen test was sensitive for differentiating dogs with malignancies of the lower urinary tr...Continue Reading

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Citations

Aug 21, 2003·American Journal of Veterinary Research·Carolyn J HenryPam Koffend Stokes
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Stephanie E Schleis
Dec 17, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Sara E Childs-SanfordAnne Hiss
Jul 11, 2003·The Veterinary Clinics of North America. Small Animal Practice·Carolyn J Henry
Jun 30, 2004·The Veterinary Clinics of North America. Small Animal Practice·S Dru Forrester
Aug 27, 2016·The Veterinary Clinics of North America. Small Animal Practice·Linda M Vap, Sarah B Shropshire
Jan 9, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Romy M HeilmannJörg M Steiner
Jan 22, 2014·Journal of the American Animal Hospital Association·Joanna K FryClint Feagin

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