Evaluation of a breast cancer risk prediction model expanded to include category of prior benign breast disease lesion.

Cancer
Rulla M TamimiGraham A Colditz

Abstract

Benign breast diseases (BBD) encompass several histologic subtypes with various risks of subsequent breast cancer. Information on previous benign breast disease biopsies has been incorporated into breast cancer risk prediction models; however, the type of histologic lesion has not been taken into account. Given the substantial heterogeneity in breast cancer risk dependent on the type of benign lesion, the authors evaluated whether incorporating this level of detail would improve the discriminatory power of risk classification models. By using data from the Nurses' Health Study, a breast cancer nested case-control study (240 cases; 1036 controls), the authors determined predictors of categories of BBD lesions and developed imputation models. The type of BBD, imputed for each cohort member who reported a diagnosis, was added to a modified version of the Rosner-Colditz breast cancer risk prediction model. Compared with the model that included only previous BBD (yes/no), the model that included categories of BBD was significantly improved (P<.0001). Overall, including the category of BBD increased the concordance statistic from 0.628 to 0.635. By using risk reclassification, inclusion of the type of BBD resulted in a 17% increase i...Continue Reading

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Citations

Nov 15, 2011·Breast Cancer Research and Treatment·Thunyarat AnothaisintaweeAmmarin Thakkinstian
Nov 3, 2012·Breast Cancer Research and Treatment·Brigid C BrowneNorma O'Donovan
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Mar 7, 2015·Breast Cancer Research and Treatment·Laureen DartoisGuy Fagherazzi
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Mar 20, 2021·Breast Cancer Research : BCR·Jonine D FigueroaThomas E Rohan

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