Evaluation of a chloride-based 89 Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin

Nuclear Medicine and Biology
S GravesJonathan W Engle

Abstract

The remarkable stability of the 89Zr-DOTA complex has been shown in recent literature. The formation of this complex appears to require 89Zr-chloride as the complexation precursor rather than the more conventional 89Zr-oxalate. In this work we present a method for the direct isolation of 89Zr-chloride from irradiated natY foils. 89Zr, 88Zr, and 88Y were prepared by 16 MeV proton irradiation of natY foils and used for batch-extraction based equilibrium coefficient measurements for TBP and UTEVA resin. Radionuclidically pure 89Zr was prepared by 14 MeV proton-irradiation of natY foils. These foils were dissolved in concentrated HCl, trapped on columns of TBP or UTEVA resin, and 89Zr-chloride was eluted in <1 mL of 0.1 M HCl. For purposes of comparison, conventionally-isolated 89Zr-oxalate was converted to 89Zr-chloride by trapping, rinsing, and elution from a QMA cartridge into 1 M HCl. Trace metal analysis was performed on the resulting 89Zr products. Equilibrium coefficients for Y and Zr were similar between UTEVA and TBP resins across all HCl concentrations. Kd values of <10-1 mL/g were observed for Y across all HCl concentrations. Kd values of >103 mL/g were observed at HCl concentrations >9 M for Zr, falling to Kd values of ...Continue Reading

Citations

Jan 18, 2018·Journal of Labelled Compounds & Radiopharmaceuticals·Eduardo Aluicio-SarduyJonathan W Engle
Apr 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anton LarenkovGalina Kodina
Sep 10, 2020·Nuclear Medicine and Biology·Heinz H Coenen, Johannes Ermert
Nov 18, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Darpan N PandyaThaddeus J Wadas
Jul 21, 2021·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Rubel Chakravarty, Sudipta Chakraborty
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ryota ImuraShigeki Watanabe

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