Evaluation of a comparative pathogenesis between cancer-associated retinopathy in humans and sudden acquired retinal degeneration syndrome in dogs via diagnostic imaging and western blot analysis

American Journal of Veterinary Research
Margi A GilmourJames F McGinnis

Abstract

To evaluate dogs with sudden acquired retinal degeneration syndrome (SARDS) for evidence of pituitary gland, adrenal gland, and pulmonary neoplasia and antiretinal antibodies and to evaluate dogs with neoplasia for antiretinal antibodies. 57 clinically normal dogs, 17 with SARDS, and 53 with neoplasia. Thoracic radiography, ultrasonography of adrenal glands, and contrast-enhanced computed tomography of pituitary glands were performed in 15 dogs with SARDS. Western blot analysis was performed on sera of all dogs; recoverin (23 kd) and arrestin (48 kd) retinal antibodies were used as positive controls. Neoplasia was not detected via diagnostic imaging in dogs with SARDS. Western blot analysis revealed bands in all dogs ranging from > 48 to < 23 kd. Prominent bands with equivalent or greater density than 1 or both positive controls at the 1:1,000 dilution, and present at the 1:3,000 dilution, were detected in 28% of clinically normal dogs, 40% of dogs with neoplasia, and 41% of dogs with SARDS. No bands in dogs with SARDS had a consistent location of immune activity, and none were detected at the 23-kd site. The area around the 48-kd site had increased immune activity in all 3 groups. The etiology of SARDS in dogs does not appear ...Continue Reading

References

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Citations

Mar 28, 2013·American Journal of Veterinary Research·Stephanie A PumphreyTanya Logvinenko
Nov 1, 2013·Journal of the American Veterinary Medical Association·Jane A StuckeyRichard W Madsen
Mar 5, 2016·Veterinary Ophthalmology·Amanda R HellerNoelle La Croix
Feb 27, 2008·The Veterinary Clinics of North America. Small Animal Practice·Sinisa D GrozdanicHelga Kecova
Apr 15, 2008·Veterinary Immunology and Immunopathology·Barbara K BrausCornelia A Deeg
Jun 19, 2013·The Journal of Veterinary Medical Science·Kunihiko TerakadoMasahiro Tagawa
Sep 3, 2009·Journal of the American Animal Hospital Association·Renee T CarterEllison Bentley

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