Evaluation of a decision aid for families considering p53 genetic counseling and testing.

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Susan K PetersonLouise C Strong

Abstract

Li-Fraumeni syndrome (LFS) is associated with p53 germline mutations, and carriers are at increased risk for multiple primary cancers. We evaluated outcomes following the administration of a video-based decision aid (DA) prior to clinical p53 genetic counseling and testing among persons who had previously participated in cancer genetics research. Fifty-seven individuals at risk for a known p53 mutation completed baseline and post-DA measures of psychological outcomes, plus knowledge and attitudes regarding p53 genetic testing. Counseling and testing uptake also was recorded. At baseline, multivariate analysis showed that greater testing intention was associated with lower decisional conflict (P < 0.01). Compared with baseline data, multivariate analyses of post-DA outcomes showed that knowledge about LFS and genetic testing increased and decisional conflict related to testing decreased (P < 0.001). Mean cancer worries scores decreased among all participants (P < 0.001), and mean depression scores decreased for males (P < 0.05). Thirty-nine (68%) completed pre-test genetic counseling and 23 (40%) subsequently gave a blood sample for clinical genetic testing. This intervention was useful as an initial outreach and educational met...Continue Reading

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Citations

Aug 19, 2007·Journal of Genetic Counseling·Nadine A KasparianBettina Meiser
May 1, 2009·Familial Cancer·D G EvansR Eeles
Apr 18, 2008·Environmental and Molecular Mutagenesis·Derek N ColeVincent L Wilson
Jul 25, 2015·Journal of Genetic Counseling·Krista Redlinger-GrosseHeather Zierhut
Sep 4, 2015·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Saskia C SandersonLynne D Richardson
Dec 17, 2008·Medical Care Research and Review : MCRR·Sheila Leatherman, Louise Warrick
Jun 8, 2017·Journal of Personalized Medicine·Rachel MillsSusanne B Haga
Jun 18, 2018·Journal of Genetic Counseling·Corinna L SchultzCarol A Ford
Nov 13, 2020·Journal of Genetic Counseling·Krista Redlinger-GrosseHeather Zierhut

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