Evaluation of a delivery system providing long-term release of cyclosporine

Archives of Ophthalmology
P Andrew PearsonP. Ashton

Abstract

To examine the clearance of cyclosporine after intravitreal injection and to assess the kinetics and toxic effects of an intravitreal device that provides sustained delivery of cyclosporine. Rabbits were divided into two groups to evaluate (1) the elimination kinetics after 1-microgram and 10-microgram intravitreal injections of cyclosporine and (2) the levels produced after implantation of a device that contained cyclosporine over 6 months. The toxic effects of the intravitreal device over 6 months were assessed in rabbits and cynomolgus monkeys. After the 10-microgram injection, the half-life was longer (10.8 hours vs. 4.2 hours) and the distribution volume was smaller (1.7 mL vs 3.2 mL) than after the 1-microgram injection. This difference can be attributed to saturable partitioning of the drug. The device resulted in a vitreous concentration of approximately 500 ng/mL throughout the study period. In the rabbit it resulted in reversible lens opacification and decreased b-wave amplitude. This toxic effect was not detected in the monkey. The device produces sustained intravitreal levels of cyclosporine. Although it was associated with reversible toxic effects in the rabbit, it was well tolerated in primates. Sustained-release ...Continue Reading

Associated Clinical Trials

Citations

Jul 11, 2012·Pharmaceutical Research·Heidi KidronArto Urtti
Jul 12, 2014·Journal français d'ophtalmologie·C Chiquet, F Rouberol
Oct 27, 1999·The British Journal of Ophthalmology·G Velez, S M Whitcup
Mar 30, 2005·Journal of Biomaterials Science. Polymer Edition·Hai-Quan MaoKam W Leong
Aug 25, 2004·Survey of Ophthalmology·Paris G TranosCarlos E Pavesio
Jan 5, 2002·Expert Opinion on Investigational Drugs·Susan Lightman, Howesen Kok
Oct 16, 2015·International Ophthalmology·Mohammed ZiaeiBita Manzouri
Nov 19, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·Felipe Piacentini Paes de AlmeidaAndre Messias
Jan 21, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eva M del AmoArto Urtti
Nov 17, 2006·Advanced Drug Delivery Reviews·J L BourgesF Behar-Cohen
Jul 11, 2006·International Journal of Pharmaceutics·O Felt-BaeyensR Gurny
Nov 18, 2005·Experimental Eye Research·Hyuncheol KimMichael R Robinson
Jul 24, 2004·The Veterinary Clinics of North America. Equine Practice·Brian C Gilger, Tammy Miller Michau
Aug 3, 2011·Progress in Retinal and Eye Research·Marc D de SmetSue Lightman
Sep 19, 2012·Mediators of Inflammation·John B ChristoforidisColleen M Cebulla
Mar 15, 2011·Therapeutic Delivery·Uday B KompellaVincent H L Lee
Jun 9, 2001·Veterinary Ophthalmology·B.C. Gilger, J.B. Allen
Dec 24, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Sarper KarakücükAynur Akin
May 3, 2000·International Ophthalmology Clinics·C L Haupert, G J Jaffe
May 26, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yuan HeQiang Zhang
Aug 17, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jennifer L DumouchelUpendra A Argikar
Feb 13, 2008·Journal français d'ophtalmologie·J-L BourgesF Behar-Cohen

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