Evaluation of a dosing regimen for continuous vancomycin infusion in critically ill patients: an observational study in intensive care unit patients

Journal of Critical Care
Bernd SaugelWolfgang Huber

Abstract

We aimed to evaluate a dosing algorithm for continuous vancomycin administration in intensive care unit patients. This observational study was conducted in a medical intensive care unit (German university hospital; June 2012-February 2013). Following a loading dose of 20 mg per kg actual body weight, vancomycin was administered continuously (20 or 30 mg of vancomycin per kg actual body weight over 24 hours depending on renal function). The vancomycin infusion rate was adjusted to achieve a target serum vancomycin concentration of 20-30 mg/L. Vancomycin was administered for a median (interquartile range) of 7 (5-9) days. The median vancomycin dose given as an initial bolus was 1750 (1400-2000) mg. The median daily vancomycin dose ranged from 480 (180-960) mg (day 6) to 3.120 (2596-3980) mg (day 1). Altogether, the achieved median serum vancomycin concentration was 29.0 (25.2-33.2) mg/L. On treatment days 1 to 7, we observed target serum vancomycin levels (20-30 mg/L) in 48%, 39%, 33%, 26%, 43%, 57%, and 69% of patients. Supra-therapeutic serum vancomycin concentrations (>30 mg/L) were observed in 36%, 52%, 61%, 63%, 39%, 19%, and 15% of patients on treatment days 1 to 7. The evaluated vancomycin dosing regimen for continuous inf...Continue Reading

References

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Citations

Aug 5, 2015·Journal of Critical Care·Lisa T HongTyree H Kiser
Dec 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·João Pedro BaptistaJorge Pimentel
Apr 14, 2015·Journal of Clinical Pharmacy and Therapeutics·M F WaineoD L Brown
Apr 28, 2016·European Journal of Clinical Pharmacology·Sepideh Elyasi, Hossein Khalili
Aug 30, 2018·Pharmacology Research & Perspectives·Joaquim F MonteiroPaula Fresco
Sep 13, 2017·Antimicrobial Agents and Chemotherapy·Susanna Edith Medellín-GaribayEmilia Barcia
May 25, 2016·Antimicrobial Agents and Chemotherapy·Stefano CristalliniFabio Silvio Taccone
Nov 15, 2018·Open Medicine·Radica Zivkovic ZaricSlobodan Jankovic
May 18, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Frieder Keller, Alexander Hann
Apr 30, 2021·International Journal of Clinical Pharmacy·Tatjana Van Der HeggenPieter A J G De Cock

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