Evaluation of a drift flux model for simulating submicrometer aerosol dynamics in human upper tracheobronchial airways

Annals of Biomedical Engineering
Jinxiang Xi, P Worth Longest

Abstract

In this study, a hybrid drift flux velocity correction (DF-VC) model that accounts for both submicrometer particle diffusion and inertia was extended to transient conditions and was tested against existing experimental deposition data measured in a replica cast of the human tracheobronchial (TB) region for laminar and turbulent flow. To evaluate the effectiveness of the DF-VC model, deposition results were compared with a standard chemical species (CS) approach that neglects particle inertia. A numerical model of the TB cast was constructed from CT images and extended from the larynx to approximately the sixth respiratory generation. Experimentally determined inlet and outlet flow conditions were implemented in the computational model to ensure direct comparisons between simulations and measurements for the deposition of 40 and 200 nm particles. A low Reynolds number k-omega turbulence model was employed to resolve the laminar and turbulent flow regimes that coexist in the TB geometry. Interesting flow characteristics were observed due to the presence of the larynx, asymmetrical ventilation, and left-right asymmetry, which created a right-skewed laryngeal jet and flow reversal in the trachea that persist over a majority of the ...Continue Reading

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Citations

Jan 10, 2012·Computer Methods in Biomechanics and Biomedical Engineering·M MalvèM Doblaré
Jul 3, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·JongWon KimWei Chung Su
Jun 7, 2011·Advanced Drug Delivery Reviews·P Worth Longest, Landon T Holbrook
Jan 15, 2013·Respiratory Physiology & Neurobiology·Xiuhua A SiHualiang Zhong
Mar 26, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Nasrul Hadi JohariMohammed A Rafiq Abdul Kadir
Nov 5, 2017·Sleep & Breathing = Schlaf & Atmung·Jinxiang XiHaibo Dong
Jun 1, 2013·Journal of Biomechanical Engineering·Ross L WalengaP Worth Longest
Mar 4, 2010·Pharmaceutical Research·Yuanyuan XieP Worth Longest
Feb 11, 2011·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Andrew R LambertChing-Long Lin
Sep 7, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Jinxiang XiYue Zhou
Jun 24, 2017·Pharmaceutical Research·P Worth Longest, Michael Hindle

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