Evaluation of a dry therapeutic urinary diet and concurrent administration of antimicrobials for struvite cystolith dissolution in dogs

BMC Veterinary Research
Jonathan D DearJodi L Westropp

Abstract

Struvite urolithiasis with bacterial urinary tract infection (UTI) is commonly reported in dogs; few data exist to describe successful dissolution protocols in dogs with naturally occurring disease. We hypothesized that a dry therapeutic urinary diet combined with targeted antimicrobial therapy can effectively dissolve presumptive struvite cystolithiasis in dogs with naturally occurring urease-producing bacterial UTI. Ten dogs with presumed infection-induced struvite cystolithiasis based on lower urinary tract signs (LUTS), radiodense cystoliths, and urease-producing bacterial UTI were enrolled. At enrollment, antimicrobials and dry therapeutic urinary diet were dispensed. In addition to lack of radiographic resolution of urolithiasis, dogs with persistent clinical signs were considered non-responders. There was no significant difference in pH between responders and non-responders; USG was significantly higher in the responder group. Recheck visits continued until radiographic dissolution or failure was documented. Five of the 10 dogs achieved radiographic dissolution of cystolithiasis within a median of 31 days (range 19-103). In the other 5 dogs, surgical urolith removal was necessary due to persistent LUTS (3 dogs within 2 w...Continue Reading

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Citations

Jul 25, 2020·Journal of Feline Medicine and Surgery·Karen M TefftNolan Z Frantz
Nov 8, 2020·Nature Reviews. Urology·Ashley AlfordJody Lulich
Mar 4, 2021·The Veterinary Clinics of North America. Small Animal Practice·Jonathan StockmanRonald Jan Corbee
May 7, 2021·Journal of Veterinary Internal Medicine·Lucy KopecnyJodi L Westropp
May 8, 2021·Journal of Veterinary Internal Medicine·Lucy KopecnyJodi L Westropp
Sep 2, 2021·Journal of Veterinary Internal Medicine·Allie M WingertEva Furrow

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Methods Mentioned

BETA
urine collection

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