PMID: 6422Apr 1, 1976

Evaluation of a dual-function pH and PCO2 in vivo sensor

Journal of Applied Physiology
R L CoonJ P Kampine

Abstract

A newly developed, dual-function pH and PCO2 sensor was evaluated in this study. The sensors were placed in the femoral arteries of dogs anesthetized with sodium pentobarbital. Comparisons were made between systemic arterial pH and PCO2 measured using the sensor and those measured from blood samples drawn at 15-min intervals over a 7-h period using a bench instrument. The mean pH of the bench instrument measurements was 7.43. The mean difference of the sensor measurements from the bench instrument measurements for 207 comparisons was 0.0003 pH +/- 0.061 SD. The mean PCO2 of the bench instrument measurements was 40 mmHg. The mean difference of the sensor measurements from those of the bench instrument for 212 comparisons was -1.43 mmHg +/- 5.17 SD. The sensors performed equally well in the presence of metabolic or respiratory acidosis and alkalosis. The dual-function sensors evaluated in this study are useful for trend monitoring of pH and PCO2 over at least a 7-h period without recalibration. With improvement in the consistency of sensor construction, these sensors will be reliable in vivo sensing devices for blood pH and PCO2 and thus valuable research and clinical instruments.

Citations

Mar 20, 1978·Pflügers Archiv : European journal of physiology·C N OlievierP H Quanjer
Jan 1, 1992·International Journal of Clinical Monitoring and Computing·B E SmithL Schlain
Jan 1, 1983·Medical & Biological Engineering & Computing·G S MargulesD C MacGregor
Jan 1, 1994·Journal of Clinical Monitoring·T LumsdenS D Riccitelli
Mar 1, 1996·Journal of Clinical Monitoring·K KurahashiY Usuda
Jan 1, 1981·Annals of Biomedical Engineering·D R Westenskow
Jan 1, 1989·Critical Reviews in Analytical Chemistry·StanisŁAw GłabFolke Ingman
Jan 1, 1983·Annals of Biomedical Engineering·G G VurekJ W Severinghaus
Jul 1, 1981·Journal of Physics E: Scientific Instruments·C E Hahn
Feb 1, 1987·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·C E Hahn
May 1, 1990·Medical & Biological Engineering & Computing·P Rolfe
Nov 1, 1994·Journal of Clinical Monitoring·T H Clutton-BrockS P Hendry
Sep 1, 1979·Circulation Research·R B CaseF S Castellana
Sep 1, 1984·Medical & Biological Engineering & Computing·M Noshiro

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