Evaluation of a logistic regression model for predicting liver necroinflammation in hepatitis B e antigen-negative chronic hepatitis B patients with normal and minimally increased alanine aminotransferase levels

Journal of Viral Hepatitis
Yao XieMing-Hui Li

Abstract

Liver necroinflammation is the indicator for treating patients with chronic hepatitis B (CHB) infection. However, there is no suitable non-invasive index for diagnosing liver necroinflammation. This study aimed to create a non-invasive index to predict liver necroinflammation in patients who lack clear-cut clinical inflammation parameters. Patients who were hepatitis B e antigen (HBeAg)-negative and underwent liver histological diagnosis, had a normal or minimally increased alanine aminotransferase (ALT) level were enrolled. Liver necroinflammation was defined as histological active index ≥4. A logistic regression model (LRM) was established based on the parameters independently associated with liver necroinflammation. Of all 550 patients, 36.73% had necroinflammation. In patients with an abnormal ALT level, the rate of necroinflammation was 52.49%. The area under the curve (AUC) of the ALT level for predicting necroinflammation was 0.655 (95% confidence interval [CI], 0.609-0.702), and that of the HBV DNA level ≥2000 IU/mL combined with an abnormal ALT level was 0.618. By using the LRM, the AUC improved to 0.769 (95% CI, 0.723-0.815) with a Youden index of 0.519 and diagnostic accuracy of 75.3%. The cutoff value ≥0.7 in the LR...Continue Reading

References

Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Feb 1, 1993·Annals of Internal Medicine·R de FranchisG Ronchi
May 29, 2001·Gastroenterology·A S LokJ H Hoofnagle
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S J Hadziyannis, D Vassilopoulos
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yao-Shih HsuYun-Fan Liaw
Jan 13, 2006·The American Journal of Gastroenterology·George N IoannouSum P Lee
May 5, 2006·Seminars in Liver Disease·Stephanos J Hadziyannis, George V Papatheodoridis
Dec 22, 2007·Journal of Hepatology·Giovanna FattovichFrancesco Donato
Oct 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George V PapatheodoridisAthanasios J Archimandritis
Apr 21, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dar-In TaiYun-Fan Liaw
Aug 26, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·François HabersetzerMichel Doffoël
Jul 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Paul MartinIra M Jacobson
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Jan 5, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Federica InvernizziPietro Lampertico
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver

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