Evaluation of a method to correct the contractility index LVdP/dt(max) for changes in heart rate

Journal of Pharmacological and Toxicological Methods
Michael MarkertBrian Guth

Abstract

In order to differentiate heart rate (HR)-induced changes from drug-induced positive or negative inotropic effects, HR-dependent effects need to be taken into account. Left ventricular (LV)dP/dt(max), the maximal value of the first derivative of a left ventricular pressure signal, is a convenient index for LV contractile state. The objective of this study was to define the normal relationship between left ventricular LVdP/dt(max) and HR in chronically instrumented, conscious dogs, primates and minipigs in our laboratory and then to use these data as the basis for developing a LVdP/dt(max)-HR-correction formula for each species. Trained Labrador-mix dogs, cynomolgus monkeys and minipigs (Goettinger) were equipped with a fully implantable radiotelemetry-based system (ITS, Maryland, USA) for the measurement of aortic pressure (AP), left ventricular pressure (LVP), ECG (lead II) and body temperature. The contractility index LVdP/dt(max) was derived from the LV pressure signal. Notocord HEM 4.2 software was used for data acquisition. For each species the relationship between LVdP/dt(max) and HR was evaluated using spontaneous HRs throughout the observation period (8-24 h) without pharmacological intervention. The formulae for the LV...Continue Reading

References

Nov 1, 1978·Circulation Research·K Sagawa
Sep 1, 1976·Cardiovascular Research·H SugaD P Kostiuk
Nov 6, 1975·The New England Journal of Medicine·S F Vatner, E Braunwald
Apr 1, 1971·The American Journal of Cardiology·E Braunwald
Jan 1, 1972·Pflügers Archiv : European journal of physiology·N M BuckleyR S Litwak
Sep 24, 1998·The New England Journal of Medicine·P K Singal, N Iliskovic
Mar 1, 1964·The American Journal of Cardiology·R L VANCITTERSR F RUSHMER
Jun 3, 2004·Journal of Pharmacological and Toxicological Methods·Brian D GuthMichael Markert
Sep 24, 2004·Journal of Pharmacological and Toxicological Methods·Michael MarkertBrian Guth
Jun 25, 2005·Journal of Pharmacological and Toxicological Methods·Gregory S FriedrichsAlan Bass
May 30, 2006·Journal of Pharmacological and Toxicological Methods·Anja KlumppBrian Guth
Jun 30, 2006·Journal of Pharmacological and Toxicological Methods·Michael K Pugsley, Michael J Curtis
Jun 23, 2007·Journal of Pharmacological and Toxicological Methods·Michael MarkertBrian Guth
Apr 20, 2011·Journal of Pharmacological and Toxicological Methods·Frank CoolsDavid J Gallacher
Apr 30, 2011·International Journal of Toxicology·R Dustan SarazanSyril Pettit
Jun 4, 2011·Journal of Pharmacological and Toxicological Methods·Michael MarkertBrian Guth

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Citations

Feb 19, 2013·Toxicology and Applied Pharmacology·Yusheng QuHugo M Vargas
Oct 3, 2015·Journal of Pharmacological and Toxicological Methods·Hai-Ming TangGregory S Friedrichs
Apr 4, 2016·Journal of Pharmacological and Toxicological Methods·M V AccardiS Authier
Apr 4, 2016·Journal of Pharmacological and Toxicological Methods·Helen PriorKathryn Chapman
Apr 12, 2016·Journal of Pharmacological and Toxicological Methods·Lewis V BuchananMichael W Gill
May 24, 2012·Journal of Pharmacological and Toxicological Methods·M K Pugsley, M J Curtis
May 20, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yuanfan WuFei Ma
Mar 9, 2021·Journal of Pharmacological and Toxicological Methods·Helen Prior, Mark Holbrook

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