PMID: 9187641Jun 1, 1997Paper

Evaluation of a model integrating protein and energy metabolism in preruminant calves

The Journal of Nutrition
Walter J J GerritsS Tamminga

Abstract

In a companion paper, a mechanistic model is described, integrating protein and energy metabolism in preruminant calves of 80-240 kg live weight. The model simulates the partitioning of nutrients from ingestion through intermediary metabolism to growth, consisting of accretions of protein, fat, ash and water. The model also includes a routine to check possible dietary amino acid imbalance and can be used to predict amino acid requirements. This paper describes a sensitivity and behavioral analysis of the model, as well as tests against independent data. Increasing the carbohydrate:fat ratio at equal gross energy intakes leads to higher simulated protein- and lower simulated fat-deposition rates. Simulation of two experiments, not used for the development of the model, showed that rates of gain of live weight, protein and fat were predicted satisfactorily. The representation of protein turnover enables the investigation of the quantitative importance of hide, bone and visceral protein in protein and energy metabolism. The model is highly sensitive to 25% changes in kinetic parameters describing muscle protein synthesis and amino acid oxidation. Comparing simulated with experimentally derived amino acid requirements shows agreeme...Continue Reading

References

Oct 1, 1990·The Proceedings of the Nutrition Society·D J MillwardD Halliday
Feb 1, 1993·The Journal of Nutrition·N J BenevengaK P Blemings
Jun 1, 1997·The Journal of Nutrition·W J GerritsJ France

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