Evaluation of a nanoemulsion-based formulation for respiratory delivery of budesonide by nebulizers.

AAPS PharmSciTech
Amir AmaniBrian J Clark

Abstract

The aim of this work was to evaluate the in vitro performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budesonide. The in vitro characteristics of the diluted nanoemulsions were then compared with the commercially available suspension of budesonide (Pulmicort Respules®) when nebulized using a jet and a vibrating mesh nebulizer. A smaller MMAD with improved aerosol output was observed in the nanoemulsion preparations compared with the corresponding suspension formulations indicating an improved in vitro performance for the nanoemulsion-based preparations.

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Citations

Nov 28, 2013·International Journal of Pharmaceutics·Maha NasrAbdelbary Elhissi
Nov 28, 2013·International Journal of Pharmaceutics·Mohammad NajlahAbdelbary Elhissi
Apr 4, 2013·Drug Development and Industrial Pharmacy·Ji-Eon KimDae-Duk Kim
Jan 14, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Maryam EsmaeiliAmir Amani
Jun 15, 2011·Journal of Pharmaceutical Sciences·Amir AmaniPeter York
Apr 12, 2016·The Journal of Pharmacy and Pharmacology·Thiago C Carvalho, Jason T McConville
Jul 5, 2015·International Journal of Pharmaceutics·Lifei ZhuYiguang Jin
Jul 31, 2012·International Journal of Pharmaceutics·Maha NasrAbdelbary Elhissi
Jul 18, 2018·Journal of Oleo Science·Noor Hafizah ArbainMohd Basyaruddin Abdul Rahman
Sep 29, 2018·Nanomedicine·Hossam H Tayeb, Frank Sainsbury
Nov 30, 2018·Expert Opinion on Drug Delivery·Regina Scherließ
Mar 16, 2018·Drug Delivery and Translational Research·Noor Hafizah ArbainMohd Basyaruddin Abdul Rahman
Jun 9, 2018·Drug Delivery and Translational Research·Cheng Loong Ngan, Azren Aida Asmawi
Jul 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Salma N TammamSanjay Mathur

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