Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimp Litopenaeus vannamei against White Spot Syndrome Virus infection

PeerJ
Carlos R Romo-QuiñonezClaudio H Mejia-Ruiz

Abstract

In this study, four experimental assays were conducted to evaluate the use of a new silver nanoparticle formulation named Argovit-4, which was prepared with slight modifications to enhance its biological activity against white spot syndrome virus (WSSV) in shrimp culture. The goals of these assays were to (1) determine the protective effect of Argovit-4 against WSSV, (2) determine whether Argovit-4 supplemented in feed exhibits toxicity towards shrimp, (3) determine whether Argovit-4 as antiviral additive in feed can prevent or delay/reduce WSSV-induced shrimp mortality, and (4) determine whether Argovit-4 supplemented in feed alters the early stages of the shrimp immune response. In bioassay 1, several viral inocula calibrated at 7 SID50(shrimp infectious doses 50% endpoint) were exposed to 40, 100, 200 and 1,000 ng/SID50 of Ag+ and then intramuscularly injected into shrimp for 96 h. In bioassay 2, shrimp were fed Argovit-4 supplemented in feed at different concentrations (10, 100 and 1,000 µg per gram of feed) for 192 h. In bioassay 3, shrimp were treated with Argovit-4 supplemented in feed at different concentrations and then challenged against WSSV for 192 h. In bioassay 4, quantitative real-time RT-qPCR was performed to me...Continue Reading

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Citlalic A Pimentel-AcostaAlejandra García-Gasca
Oct 15, 2020·Environmental Science and Pollution Research International·María-Cristina Chávez-SánchezNina Bogdanchikova
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Catrenar De SilvaSiti Aqlima Ahmad
Aug 28, 2021·Nanomaterials·Idalia Yazmin Castañeda-YslasMaría Evarista Arellano-García

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Methods Mentioned

BETA
Surface
PCR

Software Mentioned

STATISTICA

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