Evaluation of a New Design of Antireflux-biodegradable Ureteral Stent in Animal Model

Urology
Federico SoriaFrancisco M Sanchez-Margallo

Abstract

To determine the effects in urinary tract of a new antireflux-biodegradable ureteral stent. Thirty six ureters belonging to 24 pigs were used. The study began with endoscopic, nephrosonographic, and fluoroscopic assessments. Three study groups of ureters (n = 12) were then specified. In group I, a biodegradable antireflux ureteral stent (BDG-ARS) was inserted in the right ureter of 12 pigs. Group II comprised the left ureter of the same animals, in which a double-pigtail stent was placed for 6 weeks. Group III ureters, belonging to 12 additional animals, were subjected to a ureteropelvic junction obstruction model that was then treated by endopyelotomy and stenting with BDG-ARS. Follow-ups were performed at 3-6 weeks and at 5 months. None of the ureters receiving the BDG-ARS showed any evidence of vesicoureteral reflux (VUR). BDG-ARS degradation took place in a controlled and predictable fashion from the third to the sixth weeks, and no obstructive fragments appeared. No differences were found between groups I and II regarding passive ureteral dilation, but significant differences were found regarding VUR and ureteral orifice damage. BDG-ARS always maintained distal ureteral peristalsis. BDG-ARS in group III showed a 50% positi...Continue Reading

Citations

Aug 25, 2018·Journal of Biomaterials Science. Polymer Edition·Lin WangFang Chen
Dec 12, 2018·Current Opinion in Urology·Clemens G WiesingerJaime O Herrera-Caceres
Dec 14, 2019·Current Opinion in Urology·Colin J LundeenBen H Chew
Apr 7, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tsuyoshi HamadaKazuhiko Koike
Jan 15, 2020·Journal of Endourology·Federico SoriaFrancisco M Sanchez-Margallo
Aug 18, 2020·Research and Reports in Urology·Meghana RamachandraBhaskar K Somani
Mar 1, 2021·BMC Urology·Federico SoriaFrancisco M Sanchez-Margallo

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