Evaluation of a new device for noninvasive measurement of nonshunted pulmonary capillary blood flow in patients with acute lung injury

Intensive Care Medicine
Marcelo Gama de AbreuDetlev Michael Albrecht

Abstract

To evaluate the performance of a new device for noninvasive measurement of nonshunted pulmonary capillary blood flow (PCBF) by partial CO2 rebreathing. Prospective clinical trial in an intensive care unit of a university hospital. Twenty mechanically ventilated patients with acute lung injury. Variations in PEEP of +/-3 cmH2O. Initially PCBF was measured invasively as cardiac output minus venous admixture (Q(VA)/Q(t)) flow, and by partial CO2 rebreathing at baseline PEEP (PEEP(b)). The PEEP was then reduced by 3 cmH2O (to PEEP(b-3)) and measurements were repeated after 30 min. PEEP was then increased by 6 cmH2O (to PEEP(b+3)), and measurements were repeated after 10, 20, and 30 min. The overall correlation coefficient between noninvasive and invasive PCBF measurements at PEEP(b) was high ( r=0.97), with close agreement between methods being observed (0.1+/-0.6 l/min, bias and precision, respectively). Accordingly, both the correlation coefficient and agreement between methods for changes in PCBF from PEEP(b-3) to PEEP(b+3) levels were satisfactory ( r=0.71; 0.2+/-0.5 l/min, bias and precision). The new device was able to detect the correct PCBF trend in 17 of 20 patients investigated and in all patients who showed invasive PCBF...Continue Reading

Citations

Sep 22, 2005·Current Opinion in Critical Care·Bernard P Cholley, Didier Payen
Apr 1, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Astrid BotteAdelaide Richard
Jan 4, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Avihu Z Gazit, David S Cooper
Feb 19, 2010·Journal of Emergencies, Trauma, and Shock·Maximillian Ragaller, Torsten Richter
Jul 6, 2005·Intensive Care Medicine·Randolph P Cole
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Mar 9, 2007·Anesthesiology Clinics·James Ramsay
Jun 10, 2003·Emergency Medicine Clinics of North America·Debra G Perina
Dec 13, 2017·Frontiers in Medicine·Lee S Nguyen, Pierre Squara

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