PMID: 9431921Feb 12, 1998Paper

Evaluation of a new method for rapid drug susceptibility testing of Mycobacterium avium complex isolates by using the mycobacteria growth indicator tube

Journal of Clinical Microbiology
C PiersimoniG De Sio

Abstract

The reliability of the Mycobacteria Growth Indicator Tube (MGIT [BBL]) for rapid drug susceptibility testing of Mycobacterium avium complex (MAC) isolates was evaluated. MICs of amikacin, clarithromycin, clofazimine, ethambutol, and rifabutin were determined by the MGIT system for 16 MAC strains. The results were compared with those obtained by the BACTEC broth macrodilution method. The turnaround times were 6 to 8 days (median, 7 days) for the MGIT and 5 to 7 days (median, 6 days) for the BACTEC system. Agreements with BACTEC system-determined MICs, within +/-1 log2 dilution, were 100, 100, 88, 63, and 44% for amikacin, clofazimine, rifabutin, clarithromycin, and ethambutol, respectively. Within +/-2 log2 dilutions, agreement with BACTEC system-determined MICs increased to 100% for all the tested drugs. In addition, if MGIT-determined MICs were evaluated according to the thresholds adopted for the interpretation of BACTEC system-determined ones, ethambutol was the only drug for which susceptible strains were frequently misclassified as resistant. It is concluded that the MGIT system is a promising, nonradiometric alternative to the BACTEC method for rapid susceptibility testing of MAC isolates; however, additional studies are ...Continue Reading

Citations

Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Sung Jae Shin, Michael T Collins
May 22, 2009·The Journal of Antimicrobial Chemotherapy·Manju Y KrishnanMichael T Collins
Oct 24, 2014·Future Microbiology·Jakko van Ingen, Ed J Kuijper
Oct 4, 2011·The Journal of Antimicrobial Chemotherapy·Katja LuckeErik C Böttger

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