PMID: 7949375Aug 1, 1994

Evaluation of a new method using telemetry for monitoring the left ventricular pressure in free-moving rats

Journal of Pharmacological and Toxicological Methods
K SatoS Sato

Abstract

Left ventricular pressure (LVP) in free-moving rats was continuously measured for 2 weeks by a telemetry blood pressure measurement system. Prior to LVP measurement, a dummy transmitter was used to determine whether organ weights, including that of the heart and the lungs, or the stiffness of the left ventricular chamber were affected by the catheterization of the LV chamber. Organ weights did not increase, and no functional abnormalities were observed in the left ventricular pressure-volume relationship. The LVP transmitter was implanted in the left ventricle, and systolic LVP, end-diastolic LVP, LV dP/dt max, and heart rate were measured. All parameters were essentially stable during the 2-week observation period after implantation, and the values, especially the heart rate, in the dark phase tended to be higher than those in the light phase. Microscopic examination of the left ventricular wall revealed that implantation of the dummy or LVP transmitter caused no histological damage. We confirmed that LVP in free-moving rats can be measured continuously for 2 weeks without any harmful effect on cardiac function and that this telemetry system should be useful in pharmacological and toxicological studies.

References

Apr 28, 2001·Journal of Pharmacological and Toxicological Methods·B N Van VlietJ P Montani
Oct 3, 2015·Journal of Pharmacological and Toxicological Methods·Hai-Ming TangGregory S Friedrichs
Jun 1, 2015·Journal of Pharmacological and Toxicological Methods·Rob WallisHelen Maddock
Apr 11, 2006·Physiological Measurement·Xiaohui ZhaoLan Huang
Oct 12, 2013·Journal of Applied Physiology·Ellyce StehlinSarah-Jane Guild

Citations

Jan 1, 1978·Annual Review of Medicine·J A Wisneski, J D Bristow
May 1, 1992·Journal of Pharmacological and Toxicological Methods·J SchenkJ H McNeill
Jun 1, 1991·Journal of Cardiovascular Pharmacology·I HernandezL F Carbonell
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·B P BrockwayS H Azar
May 1, 1990·Circulation Research·J M CapassoP Anversa
Jul 1, 1985·Circulation Research·J M PfefferE Braunwald
Jan 1, 1962·The Journal of Clinical Investigation·W L GLEASON, E BRAUNWALD
Dec 1, 1964·Circulation Research·E M KRIEGER

Related Concepts

Lung
Left Ventricular Structure
Diastolic Blood Pressure
Blastocyst Implantation, Natural
Left Ventricular Function
Microscopy
Monitoring, Physiologic
Blood Pressure
Heart Ventricle
Rats, Wistar

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