PMID: 8968178Dec 1, 1996Paper

Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients

Anesthesiology
G J DespotisL T Goodnough

Abstract

This study was designed to evaluate a new point-of-care test (HemoSTATUS) that assesses acceleration of kaolin-activated clotting time (ACT) by platelet activating factor (PAF) in patients undergoing cardiac surgery. Our specific objectives were to determine whether HemoSTATUS-derived measurements correlate with postoperative blood loss and identify patients at risk for excessive blood loss and to characterize the effect of desmopressin acetate (DDAVP) and/or platelet transfusion on these measurements. Demographic, operative, blood loss and hematologic data were recorded in 150 patients. Two Hepcon instruments were used to analyze ACT values in the absence (channels 1 and 2: Ch1 and Ch2) and in the presence of increasing doses of PAF (1.25, 6.25, 12.5, and 150 nM) in channels 3-6 (Ch3-Ch6). Clot ratio (CR) values were calculated with the following formula for each respective PAF concentration: clot ratio = 1-(ACT/control ACT). These values also were expressed as percent of maximal (%M = clot ratio/0.51 x 100) using the mean CRCh6 (0.51) obtained in a reference population. When compared with baseline clot ratios before anesthetic induction, a marked reduction in clot ratios was observed in both Ch5 and Ch6 after protamine admini...Continue Reading

References

May 1, 1975·British Journal of Haematology·P M MannucciB Robertson
Mar 1, 1992·The Annals of Thoracic Surgery·J S WangM W Yang
Sep 1, 1991·Anesthesiology·C S RinderR Hillman
Jan 3, 1991·The New England Journal of Medicine·J N George, S J Shattil
May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F HardyM Carrier
Feb 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·F Snyder
Jul 1, 1989·Anesthesia and Analgesia·K J TumanA D Ivankovich
May 29, 1986·The New England Journal of Medicine·L A Harker
Nov 16, 1985·British Medical Journal·A K BurroughsN McIntyre
Apr 1, 1984·Anesthesia and Analgesia·M T MooreheadB S Bull
Jan 6, 1983·The New England Journal of Medicine·P M MannucciT S Zimmerman
Jan 1, 1995·Seminars in Thrombosis and Hemostasis·K H BeckV Kretschmer
Jul 1, 1994·The Annals of Thoracic Surgery·G P GravleeJ J Stuart
Apr 1, 1994·The Annals of Thoracic Surgery·M J RayM O'Brien
Aug 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·G DiltheyJ A Richter
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M CattaneoP M Mannucci

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Citations

Dec 3, 2003·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Fumio FukumuraHiromichi Sonoda
Jun 13, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pierre Sié, Annick Steib
Feb 6, 1998·Transfusion Science·L T Goodnough, G J Despotis
Oct 24, 2002·British Journal of Anaesthesia·F ForestierG Janvier
Apr 5, 2001·International Anesthesiology Clinics·M Cobas
Jun 11, 2002·Journal of Interventional Cardiology·Christopher M Thompson, Steven R Steinhubl
Aug 9, 2003·Thrombosis Journal·Domenico Prisco, Rita Paniccia
Mar 12, 1998·Anesthesia and Analgesia·B Celebioglu
Oct 20, 1998·American Heart Journal·S D BerkowitzR S Hillman
Apr 15, 2014·TheScientificWorldJournal·Kakali Ghoshal, Maitree Bhattacharyya
Feb 21, 2002·Journal of Cardiothoracic and Vascular Anesthesia·Linda Shore-Lesserson
Apr 22, 2014·Blood Reviews·Paul W A JanssenChristian M Hackeng
Jan 13, 2001·Seminars in Thoracic and Cardiovascular Surgery·B L MilasR C Gorman
Apr 17, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·T F SlaughterC S Greenberg
Oct 27, 2012·The Annals of Thoracic Surgery·Victor A FerrarisUNKNOWN Society of Thoracic Surgeons
Jan 24, 2007·Thrombosis Research·Paul HarrisonAlan D Michelson
Oct 11, 2008·The British Journal of Surgery·K J DickinsonS Homer-Vanniasinkam
Jul 14, 2010·British Journal of Haematology·David J PerrySue Mallett
May 18, 2012·Transfusion·Lawrence Tim Goodnough, Charles C Hill
Nov 14, 2006·The American Journal of Cardiology·Arthur W BraceyNancy A Nussmeier
May 20, 1998·American Heart Journal·N S NicholsonA K Salyers
Aug 31, 2000·The Annals of Thoracic Surgery·G J Despotis, L T Goodnough
Feb 18, 2015·Thrombosis Journal·Nahreen TynngårdSofia Ramström
Jan 1, 1998·Hematology·C P Price
Mar 5, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Robert PostonTimothy B Gilbert
Jul 13, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Juergen KoscielnyReinhard Latza
Apr 20, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Juergen KoscielnyReinhard Latza

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